Results 191 to 200 of about 55,221 (243)

Research on geographic information update index of RTK location big data. [PDF]

Sci Rep
Zeng X, Zhou F, Ao M, Chen C.
europepmc   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

FSCA-EUNet: Lightweight Classification of Stacked Jasmine Bloom-Stages via Frequency-Spatial Cross-Attention for Industrial Scenting Automation. [PDF]

Foods
Chen Z, Tian Z, Zhang H, Zhang X, Zhu X, Dong C.   +5 more
europepmc   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Numerically exact configuration interaction at quadrillion-determinant scale. [PDF]

Nat Commun
Shayit A, Liao C, Upadhyay S, Hu H, Zhang T, DePrince Iii AE, Yang C, Li X.   +7 more
europepmc   +1 more source

An electrostatic repulsion model of centromere organisation

Bell C, Chen L, Maristany MJ, Blaukopf C, Zhou H, Huertas J, Perez Lopez JI, Langer CCH, Steinacker TL, Schuette N, Doolittle L, Espinosa JR, Redding S, Collepardo-Guevara R, Rosen MK, Gerlich DW.   +15 more
europepmc   +1 more source

PyChelator: a Python-based Colab and web application for metal chelator calculations. [PDF]

BMC Bioinformatics
Spahiu E, Kastrati E, Amrute-Nayak M.
europepmc   +1 more source

MEGDTA: multi-modal drug-target affinity prediction based on protein three-dimensional structure and ensemble graph neural network. [PDF]

BMC Genomics
Hou Z, Li Y, Zhai H, Luo J, Ding Y, Pan Y.   +5 more
europepmc   +1 more source

An improved lightweight tongue segmentation model with self-attention parallel network and progressive upsampling. [PDF]

Sci Rep
Wang X, Cao Y, Chen Y, Li H, Han A, Tang Y.   +5 more
europepmc   +1 more source

Development of a cloud-based estimator for analysing the disc-fovea angle in fundus images using a stacking ensemble model. [PDF]

BMJ Open Ophthalmol
Hirota M, Watanabe M, Sasaki K, Kato K, Usui C, Mizuno Y, Hayashi T, Inoue Y, Mizota A.   +8 more
europepmc   +1 more source