Results 91 to 100 of about 8,606,277 (343)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Genome-Wide Identification of the HD-ZIP Transcription Factor Family in Maize and Functional Analysis of the Role of ZmHD-ZIP23 in Seed Size

Plants
HD-ZIP proteins (homeodomain–leucine zipper proteins) are a large family of plant-specific transcription factors that play crucial roles in regulating various physiological and developmental processes, including growth, differentiation, response to ...
Jinghua Zhang, Xuan Zhang, Mengru Liu, Yichen Jin, Qiaofeng Pai, Xiaolin Wu, Doudou Sun   +6 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Integration of multi-omics data accelerates molecular analysis of common wheat traits

Nature Communications
Integration of multi-omics data can provide information on biomolecules from different layers to illustrate the complex biology systematically. Here, we build a multi-omics atlas containing 132,570 transcripts, 44,473 proteins, 19,970 phosphoproteins ...
Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen   +18 more
doaj   +1 more source

Double Trouble

Indian Journal of Endocrinology and Metabolism, 2023
S V Madhu, Nishant Raizada
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Double X Configuration Screw Fixation for Middle Phalanx Fracture – A Case Report

Journal of Orthopaedic Case Reports
Introduction: Techniques for treating phalangeal fractures are evolving. Intramedullary screws are a trendy surgical choice that leads to optimal results. Metacarpals and proximal phalanges could tolerate two screws.
Mojahed Sakhnini
doaj   +1 more source

From Kant to Dostoyevsky: Dmytro Čyževs’kyj’s Literary Anthropology [PDF]

Slovo a Smysl
This paper reconstructs the core argument of Dmytro Čyževs’kyj’s unfinished project on formalism in ethics, developed in the late 1920s during his exile in Prague.
Patrick Flack
doaj   +1 more source

Erratum: A Compact Scattering Model for the Nanoscale Double-Gate MOSFET [Mar 02 481-489] [PDF]

, 2015
Anisur Rahman, Mark Lundstrom
openalex   +1 more source