Results 51 to 60 of about 8,606,277 (343)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Miguel de Molina dans Ésta es mi vida (1952) de Román Viñoly Barreto : le cinéma, de concert avec la musique, ou les multiples possibles du vrai et du faux

Itinéraires
This article aims to show how Román Viñoly Barreto's Argentine feature-length fiction film Ésta es mi vida (1952) is an example of a specific, inventive and sophisticated cinematographic staging of the art of music transubstantiated on the big screen. It
Emmanuel Le Vagueresse
doaj   +1 more source

Double, Double Toil and Trouble [PDF]

Molecular Syndromology, 2015
With the complete sequence of the human genome being available, systematic mapping of regions of transcription, transcription factor binding, chromatin structure and histone modification has revealed that 80% of the genome outside of the protein-coding regions performs essential biochemical functions [ENCODE, 2012].
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Double Trace Interfaces

, 2017
We introduce and study renormalization group interfaces between two holographic conformal theories which are related by deformation by a scalar double trace operator.
Melby-Thompson, Charles, Schmidt-Colinet, Cornelius   +1 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Ulysse et son double

Annali Online dell'Università di Ferrara. Sezione Lettere, 2018
Odysseus’s dual personnality, both positive and negative, reflects the dual personnality of the god Hermes, the god in which opposite forces are united. So he faces recurrently «doubles» reproducing the dark face of his contradictory personnality, namely
Jean-Michel Ropars
doaj   +1 more source

The Hollywood Dance-In: Abstract and Material Relations of Corporeal Reproduction

Arts, 2019
This essay asks what the figure of the Hollywood dance-in—a dancer who performed in place of a star prior to filming and who assisted the choreographer in the creation of dance numbers—can reveal about the reproduction of corporeality as an ...
Anthea Kraut
doaj   +1 more source