Results 141 to 150 of about 2,247,060 (230)

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

open access: yesPhytotherapy Research, Volume 40, Issue 11, Page 6670-6684, November 2026.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao   +6 more
wiley   +1 more source

PDA‐Engineered 3D‐Printed Polymer–ZrO2 Hybrid Scaffolds Enabling Enhanced Radiopacity, Photothermal Therapy, and Cell Migration Modulation

open access: yesSmall, Volume 22, Issue 61, 2 November 2026.
A multifunctional 3D‐printed polymer–ZrO2 scaffold is developed to provide intrinsic radiopacity, photothermal responsiveness, and surface bioactivity. Reinforcement with ZrO2 enables real‐time x‐ray visibility and mechanical robustness, while a polydopamine coating facilitates near‐infrared‐triggered drug release and modulates cell migration, thereby ...
Sumin Kang   +10 more
wiley   +1 more source

Prediction of coarctation of the aorta in fetuses with transposition of great arteries: Inverted ventricular discrepancy as a predictor of arch repair in TGA

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 11, Page 2359-2366, November 2026.
Fetal MV/TV ratio offers a simple and reproducible marker of AAO in TGA with a cutoff of ≥ 1.0 accurately predicting the need for arch repair. This simple echocardiographic marker improves prenatal risk stratification and surgical planning, facilitating prenatal counseling. Abstract Introduction Transposition of great arteries (TGA) with coarctation of
Cosimo Marco Campanale   +5 more
wiley   +1 more source

Multiple cardiac malformations in a calf

open access: yesAustralian Veterinary Journal, Volume 104, Issue 11, Page 777-781, November 2026.
This paper describes the morphopathological aspects of a case of multiple cardiac malformations in a calf. A two‐day‐old male calf of undefined breed was born with an ectopic heart, presenting with dyspnoea and in lateral recumbency. The owner had repositioned the exposed heart beneath the adjacent skin, which was suclosed, without additional incisions
LA Soares   +7 more
wiley   +1 more source

Genetics in Heterotaxy: A Case Series and Literature Review on DNAH9, PKD1L1, MMP21, and GDF1

open access: yesClinical Genetics, Volume 110, Issue 5, Page 574-583, November 2026.
Integrating trio‐based genomic sequencing with detailed clinical evaluation across seven French–Vietnamese heterotaxy cases alongside a review of 108 published patients reveals strong genotype–phenotype correlations. Variants in DNAH9, PKD1L1, MMP21, and GDF1 define a broad spectrum from isolated situs inversus to complex conotruncal heart defects and ...
Thi Bich Tuyen Ho   +23 more
wiley   +1 more source

Double Aortic Arch: An Uncommon Cause of Pediatric Airway Compression

open access: yes
Double aortic arch (DAA) is a rare congenital anomaly of the aortic arch that forms a complete vascular ring, causing compression of both the trachea and esophagus. The diagnosis is often made only after the child becomes symptomatic.
Avanish Kant Malhotra, Sambhunath Das
core   +1 more source

Incidence of Intensive Care Unit Delirium After Heart Surgery: A Feasibility Study of a Forest Environment Intervention

open access: yesNursing in Critical Care, Volume 31, Issue 6, November 2026.
ABSTRACT Background Postoperative delirium is a serious complication in intensive care units (ICUs), particularly following cardiac surgery. It is associated with circadian rhythm disruption, sleep disturbances and adverse outcomes. ICU environments often lack natural time cues, which may exacerbate circadian misalignment and increase delirium risk ...
Jolana Wagner‐Skacel   +18 more
wiley   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

open access: yesExperimental Physiology, Volume 111, Issue 11, Page 4966-4978, 1 November 2026.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey   +14 more
wiley   +1 more source

Endothelial Matrin‐3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Endothelial Matrin‐3 suppresses cellular senescence and protects against atherosclerosis. Matrin‐3 deficiency induces endothelial senescence, mitochondrial dysfunction, and activation of p53‐, cell cycle‐, and senescence‐related pathways. In atherosclerosis‐prone mice, endothelial Matrin‐3 deletion promotes atherosclerotic lesion formation and disrupts
Xiao Cheng   +5 more
wiley   +1 more source

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