Results 271 to 280 of about 1,250,392 (346)

Evaluation of safe utilization of L-threonine for supplementation in healthy adults: a randomized double blind controlled trial. [PDF]

Amino Acids
Matsumoto H, Miura N, Naito M, Elango R.
europepmc   +1 more source

Sparse Nanocrystals Enable Ultra‐Low Coercivity and Remarkable Mechanical Robustness in High‐Entropy Amorphous Alloy

Advanced Science, EarlyView.
An order modulation strategy is introduced to overcome trade‐off between mechanical and magnetic properties by constructing an amorphous‐nanocrystalline transitional structure in a ferromagnetic HEA system. This enable the resultant alloys to combine an ultra‐low coercivity of 0.3 A m−1 with a remarkable mechanical toughness, thereby achieving a ...
Lichen Liu, Liliang Shao, Yan Ma, Zhilin Wen, Jing Zhou, Yuqiang Yan, Weiming Yang, Haibo Ke, Weihua Wang   +8 more
wiley   +1 more source

Efficacy and safety of anrikefon in patients with pruritus undergoing haemodialysis: multicentre, double blind, randomised placebo controlled phase 3 trial.

BMJ
Liu BC, Li ZL, Zhang P, Zhong AM, Bai YL, Xu Y, Gao BH, Li YL, Wang Y, Zhou LH, Yao L, Wang JX, Yan R, Wang L, Liao B, Xie DQ, Yi XM, Guan TJ, Wang CL, Li GS, Li FQ, Chen JH, Anrikefon-302 study collaborator group.   +22 more
europepmc   +1 more source

Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: a double-blind randomized trial. [PDF]

Nat Commun
Ryffel C, Lanz J, Guntli N, Samim D, Fürholz M, Stortecky S, Tomii D, Heg D, Boscolo Berto M, Peters AA, Reineke D, Reichlin T, Gräni C, Windecker S, Pilgrim T.   +14 more
europepmc   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Standard treatment regimen with and without dexamethasone on outcome of children aged 3-7 years with empyema: a randomized double blind clinical trial. [PDF]

Ital J Pediatr
Eshghi A, Nejad NH, Mohammadzadeh A, Mansouri F, Aghajani S.   +4 more
europepmc   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

A Randomized Double-Blind Controlled Evaluation of the Therapeutic Benefits of an Herbal Lip Hydrant. [PDF]

J Cosmet Dermatol
Sutthiboonyapan P, Sriratanasak N, Innets B, Angkanaporn N, Suntornchot P, Panyain W, Porntaveetus T, Wiriyakijja P, Chanvorachote P.   +8 more
europepmc   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source