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Is Your ‘Double-Blind’ Design Truly Double-Blind?
British Journal of Psychiatry, 1989 Before a drug trial, researchers reasonably plan that participants will remain ignorant of which drug each patient is taking, reflected in the use of allegedly identical preparations. However, only rarely is this plan subjected to systematic scrutiny after the event, and our point of view is that this is unsatisfactory.A, Oxtoby, A, Jones, M, Robinsonopenaire +2 more sourcesPembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial.
Journal of Clinical Oncology, 2019 PURPOSE
Pembrolizumab demonstrated antitumor activity and safety in the phase II KEYNOTE-224 trial in previously treated patients with advanced hepatocellular carcinoma (HCC).R. Finn, B. Ryoo, P. Merle, M. Kudo, M. Bouattour, Ho Yeong Lim, V. Breder, J. Edeline, Y. Chao, S. Ogasawara, T. Yau, M. Garrido, S. Chan, J. Knox, B. Daniele, S. Ebbinghaus, E. Chen, A. Siegel, A. Zhu, A. Cheng +19 moresemanticscholar +1 more sourceRandomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.
Journal of Clinical Oncology, 2019 PURPOSE
SARC024 is a phase II clinical trial of the multikinase inhibitor regorafenib in specific sarcoma subtypes, including advanced osteosarcoma. We hypothesized that regorafenib would improve progression-free survival (PFS) in patients with sarcoma ...L. Davis, V. Bolejack, C. Ryan, K. Ganjoo, E. Loggers, S. Chawla, M. Agulnik, M. Livingston, D. Reed, V. Keedy, D. Rushing, S. Okuno, D. Reinke, R. Riedel, S. Attia, L. Mascarenhas, R. Maki +16 moresemanticscholar +1 more sourceDouble-blind under review
Nature Nanotechnology, 2014 Can peer review be improved by withholding information from referees? There is some evidence to suggest it might be, but the jury is still out, reports Alastair Brown.openaire +2 more sourcesThe Double-Blind Dilemma
JAMA: The Journal of the American Medical Association, 1973 To the Editor.— Double-blind studies have so often failed to add reliability to assays of therapeutic effectiveness that wits are now wont to say "it's the blind leading the blind." Though the procedure has merit in some situations, it will not prevent the poor observer from making false-positive or false-negative decisions. Rascals, on the other hand,openaire +2 more sourcesdouble-blind"double-bind.
Current medical research and opinion, 1975 In a double-blind trial over a 2-week period in 34 patients with psoriases vulgaris, clobetasol propionate cream was shown to be more effective than betamethasone valerate cream. In a further 16 patients whose psoriasis had not responded to betamethasone valerate ointment, treatment with clobetasol propionate ointment was substituted.A, Björnberg, L, Hellgrenopenaire +1 more sourceBlind and Double-Blind Techniques
JAMA: The Journal of the American Medical Association, 1969 To the Editor:— This communication is stimulated by Dr. A. Hoffer's letter to The Journal claiming historic priority for the first double— blind study in psychiatry.1 My historic research, not yet completed, indicates that the first double-blind study was done by Rivers (1908) in experimental psychology.2The termdouble-blindwas not used to describe ...openaire +1 more sourceDulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.
The Lancet, 2019 H. Gerstein, H. Colhoun, G. Dagenais, R. Diaz, M. Lakshmanan, P. Pais, J. Probstfield, J. Riesmeyer, M. Riddle, L. Rydén, D. Xavier, C. Atisso, L. Dyal, S. Hall, P. Rao-Melacini, G. Wong, Á. Avezum, J. Basile, N. Chung, I. Conget, W. Cushman, E. Franek, N. Hancu, M. Hanefeld, S. Holt, P. Janský, M. Keltai, F. Lanas, Lawrence A Leiter, P. López-Jaramillo, Ernesto German Cordona Munoz, V. Pirags, N. Pogosova, P. Raubenheimer, J. Shaw, W. Sheu, T. Temelkova-Kurktschiev, M. Abella, Andrea Alebuena, S. Almagro, E. Amoroso, Paula Anadon, Elizabeth Andreu, G. Aristimuño, Maria Arzadun, M. Barbieri, Raúl J. Barcudi, Ines Bartolacci, Gabriel Bolobanich, Anselmo P Bordonava, M. B. Labarta, B. Bustos, A. Caccavo, A. Camino, M. Cantero, M. Carignano, L. Cartasegna, M. Cipullo, V. Commendatore, Victoria Conosciuto, O. Costamagna, C. Crespo, J. Cuello, C. Cuneo, S. Cusimano, S. Dean, Claudio Dituro, Andrea Domínguez, M. Farah, Alberto Fernández, Florencia Fernández, A. Ferrari, Patricia Flammia, J. Fuentealba, Karina Beatriz Gallardo, Celso Garcia, R. Duran, M. Garrido, Rodolfo Gavícola, Claudio Gerbaudo, G. Gilli, A. P. Giotto, Pedro Godoy Bolzán, O. Vilamajó, Fernando Guerlloy, Cristian Guridi, N. Garrido, E. Hasbani, S. Hermida, M. Hominal, A. Hrabar, A. Ingaramo, Alejandra Izzicupo, Mario Krynski, M. Lagrutta, Paulina Lanchiotti, M. Langhe, V. Leonard, J. Llanos, R. L. Santi, J. Lowenstein, C. Luquez, I. Mackinnon, Melina Mana, S. Manzur, Javier Marino, C. Martella, R. Martinez, Reinaldo Matias, Javier Matkovich, Monica Meritano, O. Montaña, M. Mulazzi, J. Ochoa, G. Paterlini, María Pelagagge, María Elena Alvarez Lopez, A. Prado, Lorena Pruyas, M. Racca, C. Ricotti, C. Rodriguez, Mariano Romero Vidomlansky, R. Ronderos, Ana Laura Sadowski, Jorgelina Sala, Alejandro Sánchez, A. Santoro, L. Schiavi, M. Sein, V. Sernia, L. Serra, M. Sicer, Tomas Smith, L. Soso, G. Sposetti, A. Steinacher, J. Stival, Jorge Tedesco, Hugo Tonin, M. Tortolo, M. Ulla, Julio A. Vallejos, M. Vico, Luciana Virgillito, Virginia Visco, D. Vogel, Florencia Waisman, C. Zaidman, N. Zucchiatti, Imran Badshah, N. Cohen, P. Colman, D. Colquhoun, T. Davis, S. Fourlanos, G. Fulcher, J. Hamlyn, Cilla J Haywood, S. Hocking, Maeve Huchinson, W. Jeffries, Mervyn Kyl, C. Lo, PeakMann Mah, A. Makepeace, Dolly Marope, Natalie Nanayakkar, A. Nankervis, N. Palmer, Barbara Palolus, S. Pillai, S. Price, J. Proietto, A. Reutens, N. Rodrigo, Abdul Sheikh, Greg Smith, Michelle So, G. Soldatos, B. Stuckey, P. Sumithran, H. Teede, Parind P Vora, L. Williams, E. Abib, Christiani Adão Poço, É. Alves, Janaina Andreatta Bernardi Barea, L. Oliveira, D. Castro, I. Cruz, Midiã Costa, I. Cruz, Sidney Cunha, Marco A.C.P. Da Silva, R. Bona, B. Paula, F. Eliaschewitz, G. Fazolli, Carlos Alberto Fruet Filho, J. Fortes, César França, D. Franco, Paulo Roberto Genestreti, F. Giorgeto, R. Gonçalves, Michele Elka Grossman, A. C. Marcelino, M. Hernandes, A. Horta, C. Jaeger, Midia Kaneblai, Cecilia Kauffman Rutenberg, J. Saraiva, M. A. Lemos, L. Maia, E. Manenti, Mariana Marques, C. Valério, R. Moreira, Flávia Mothé, O. Mouco, P. Moura, J. C. Jorge, Carlos A K Nakashima, M. Nakazone, T. Napoli, Cristiane Nunes, J. Salles, Karla Oliveira, Marcela Oliveira, Gracielly de Souza Pantano, Fabio Petri, L. Piazza, A. C. Pires, P. Pizzato, S. Prata, D. Précoma, R. Rech, Gilmar Reis, Heleno R. Reis, E. Resende, J. Fortes, S. Rodovalho, Fabio Rossi dos Santos, J. Salles, C. R. Sampaio, Thiago Santos, V. Santos, T. Quadros, D. Silveira, Katia Nunes Siqueira, M. Teireira, M. Uehara, C. Valerio, H. Vianna, M. Vidotti, G. Visconti, M. Zanella, V. Andreeva, Radoslav Borisov, N. Botushanov, G. Dimitrov, Kameliya Dimova, Tsvetan Dragoychev, V. Grigorova, Valentina Gushterova, I. Ivanov, Tatyana Kocelova, D. Kurktschiev, M. Miletieva, Neli Nenkova-Gugusheva, R. Pancheva, M. Pavlova, D. Raev, V. Spasova, A. Stoikov, Dimitar Troev, Todor Yanev, Mariana Yoncheva-Mihaylova, Alexander Abitbol, B. Ajala, Abdullh Alguwaihes, J. Ardilouze, N. Aris-Jilwan, A. Arnaout, R. Aronson, N. Aslam, S. Babin, Jean-Patrice Bailargeon, Allan Bailey, H. Bajaj, Christian Beauchesne, Sorin Beca, A. Bélanger, A. Bell, D. Bellabarba, L. Berard, B. Berenbaum, Vincent Bergeron, J. Berlingieri, F. Bernier, Phoebe Bishara, D. Blank, I. Blumer, Suzanne Brault, Donald Breton, A. Carpentier, James Cha, P. Chandra, J. Chiasson, J. Conway, Ghyslaine Couture, N. Couture, G. Dagenais, Dyotirmoy Datta, G. D'Ignazio, R. Dumas, D. Fay, André Fréchette, L. Frenette, Da-An Fung, N. Gagnon, Meri Galter, J. Garon, Jean-Sébastien Gauthier, Christian Geadah, J. Gilbert, Ronald Girard, R. Goldenberg, L. Grossman, N. Gupta, J. Hallé, M. Hivert, G. Houde, R. Houlden, I. Hramiak, Ted Jablonski, A. Jain, H. Khandwala, M. Khosla, C. Lachance, Emilie Laflamme, M. Langlois, L. Larivée, J. Liutkus, H. Lochnan, Saleem Malik, C. McDonald, Pravinsagar Mehta, John Mihailidis, A. Milot, P. Narula, P. Nault, Arun Nayar, W. Nisker, Gilles Ouellet, J. Palardy, M. Patel, Terri Paul, S. Pedersen, P. Perron, M. Pesant, P. Poirier, Marie-Claude Poulin, Z. Punthakee, Waheed Rehman, S. Ross, P. Sagar, Nouhad Saliba, S. Sandler, A. Schiffrin, R. Schlosser, Anila Seth-Sharma, M. Sherman, David Sionit, T. Sivakumar, J. Soto, E. St-Amour, Oren Steen, J. Sussman, A. Telner, S. Tobe, David Twum-Barima, A. V. Zanten, Nicole VanRossum, J. Vecchiarelli, Rick Ward, John Wessengel, S. Weisnagel, I. Wilderman, V. Woo, N. Yakubovich, J. Yale, Z. Yared, M. Acevedo, Maria Loreto Aguirre, A. Aizman, M. Barroso, L. Cobos, Alfredo Danin Vargas, Bárbara Descalzi, Gonzalo Godoy, Elio Grumberg, R. Lahsen, G. Larenas, Eugenia Ortiz, Javier Paredes, S. Potthoff, Eva Retamal, Luis Rojas, M. Salgado, C. Santibáñez, C. Solis, B. Stokins, J. Accini, Javier Acebedo, L. Baena, Soraya Alarcon, J. Angel, E. Arcos, M. A. Martinez, Leonor Atuesta, Jose Balaguera, Doris Ballestas, Sandra Isabel Barrera, Rosmy Barrios Reyes, Adolfo Bayona, Andrés Bermúdez, Diego Zarate Bernal, Marco Blanquicett, V. Bravo, W. Bueno, Alvaro Burbano Delgado, A. Cadena, A. Cadena, S. Caicedo, C. Celemin, Ricardo Consuegra, Cristhian Contreras Pimienta, K. Corredor, C. Cure, Lizeth Dayana De La Hoz Rueda, E. Delgado, S. Díaz, M. Diego, Anabell Donado, W. E. Sanabria, J. Escobar, Gillian Escorcia, L. Forero, Laura Fuentes, María García, H. G. Lozada, L. G. Ortiz, Á. Giraldo, L. Gonzalez, Javier Granada, C. Gutierrez, N. Henao, Edwin Hernandez, Olga Maria Herrera Uejbe, Juan Diego Higuera Cobos, J. Gómez, Edwin Hernandez Jaimes, Mónica Jaramillo, N. Jaramillo, C. J. Gomez, M. Sanchez, Ivonne Jarava Durán, C. Ceballos, Claudia Madrid, Elias María Amastha, Jennifer Mercado, D. I. Molina, J. Soto, C. Montoya, Alexander Morales, C. Muñoz, L. A. Orozco, Oscar Osorio, J. Sanchez, A. Peña, J. Perez, Juan Perez Agudelo, German Amador, C. Pertuz, I. Posada, C. Puerta, Adalberto Quintero, D. Quiroz, Carmen Rendon, A. Reyes, Álvaro Reyes, D. Ripoll, C. Rivera, Maria Rocha, José F. Rodriguez, Kervis Asid Rodriguez Villanueva +499 moresemanticscholar +1 more sourceAssuring That Double-Blind Is Blind
American Journal of Psychiatry, 2010 Roy H, Perlis, Michael, Ostacher, Maurizio, Fava, Andrew A, Nierenberg, Gary S, Sachs, Jerrold F, Rosenbaum +5 moreopenaire +2 more sources