Results 31 to 40 of about 1,217,627 (297)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Full spectrum cannabidiol-rich extract reduced propofol dosage required for anesthetic induction in dogs—a pilot study

Frontiers in Veterinary Science
IntroductionCannabinoids show great therapeutic potential, but their effect on anesthesia still remains unclear. Use of chronic recreational Cannabis in humans undergoing anesthetic procedures tends to require a higher dose when compared to non-users. On
João Lourenço Hasckel Gewehr, Maria Laura Enzele, Lucas Marlon Freiria, Morgana Martins Nunes, Júlia Spengler, Ana Paula Dondoerfer Teixeira, Erik Amazonas, Erik Amazonas, Vanessa Sasso Padilha   +8 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]

, 2007
Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor, Bačić Vrca, Vesna, Biočina, Bojan, Brkić, Kristina, Ivković, Mira, Rudež, Igor, Sutlić, Željko, Unić, Daniel   +7 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Attitudes toward open peer review among stakeholders of a scholar-led journal in Brazil

Transinformação, 2021
Scholarly journals should consider the attitudes of their communities before adopting any of the seven traits of open peer review. Unfortunately, surveys from the Global North might not apply to the Global South, where double-blind peer review is ...
Leonardo Ferreira Fontenelle, Thiago Dias Sarti   +1 more
doaj   +1 more source

Detectability of Terrestrial Planets in Multi-Planet Systems: Preliminary Report

, 2008
We ask if Earth-like planets (terrestrial mass and habitable-zone orbit) can be detected in multi-planet systems, using astrometric and radial velocity observations.
A. F. Boden, A. Gould, A. Howard, A. P. Boss, A. Sozzetti, C. Beichman, C. Zhai, Cumming, D. Fischer, D. Lin, D. Savransky, E. B. Ford, G. P. Laughlin, H. F. Levison, J. Catanzarite, J. Marr, M. Muterspaugh, M. Shao, N. J. Kasdin, S. Casertano, S. Halverson, S. Ida, S. N. Raymond, Scargle, V. Makarov, W. A. Traub   +25 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sublingual Immunotherapy with House Dust Extract for House Dust-Mite Allergic Rhinitis in Children

Allergology International, 2010
Background: House dust extract is used in conventional immunotherapy for house dust-mite (HDM) allergic rhinitis in Japan. However, an alternative administration route is desired.
Syuji Yonekura, Yoshitaka Okamoto, Daiju Sakurai, Shigetoshi Horiguchi, Toyoyuki Hanazawa, Atsuko Nakano, Fumiyo Kudou, Yuji Nakamaru, Kohei Honda, Akira Hoshioka, Naoki Shimojo, Yoichi Kohno   +11 more
doaj   +1 more source

Finding a needle in a haystack: toward a psychologically informed method for aviation security screening [PDF]

, 2014
Current aviation security systems identify behavioral indicators of deception to assess risks to flights, but they lack a strong psychological basis or empirical validation. We present a new method that tests the veracity of passenger accounts.
Dando, C.J., Dando, C.J., Ormerod, T.C., Ormerod, T.C.   +3 more
core   +1 more source