Results 51 to 60 of about 3,851,688 (392)

Complementary music therapy for cancer patients in at-home palliative care and their caregivers: protocol for a multicentre randomised controlled trial [PDF]

, 2020
Background Patients with advanced cancer, receiving at-home palliative care, are subject to numerous symptoms that are changeable and often require attention, a stressful situation that also impacts on the family caregiver.
Barón López, Francisco Javier, Casals Vázquez, Cristina, Espinar Toledo, Milagrosa, Martínez Valero, Francisco Javier, Valero Cantero, Inmaculada, Vázquez Sánchez, María Ángeles   +5 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Efficacy and Patient-Reported Outcomes of a New Mometasone Cream Treating Atopic Eczema [PDF]

, 2012
This double-blind controlled phase II study was conducted to compare a newly developed formulation of mometasone furoate with a water content of 33% (Monovo (R) Cream) and with a smooth consistency versus the commercially available fatty cream of ...
Ruzicka, Thomas, Wigger-Alberti, Walter, Willers, Christoph   +2 more
core   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source

Forms of identity. Ireland, Language and Translation [PDF]

, 2014
Questo volume include una serie di articoli su lingua, traduzione e identit\ue0 in Irlanda raccolti con un 'call for paper' internazionale e selezionati con un processo di 'double-peer blind review'
Monica Randaccio
core   +2 more sources

Domain Specific Placebo Response in the Modified Friedreich's Ataxia Rating Scale

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The placebo response in clinical trials in ataxias complicates outcome interpretation and potentially obscures genuine treatment effects. We analyzed placebo group data from past trials in Friedreich Ataxia and observed notable responses in appendicular items, in contrast to minimal changes in axial function, as measured by respective ...
Christian Rummey, Jennifer M. Farmer, David R. Lynch   +2 more
wiley   +1 more source

The furan microsolvation blind challenge for quantum chemical methods: First steps [PDF]

, 2018
© 2018 Author(s). Herein we present the results of a blind challenge to quantum chemical methods in the calculation of dimerization preferences in the low temperature gas phase.
Al-Mogren, Muneerah M., Antony, Jens, Auer, Alexander A., Baptista, Leonardo, Benoit, David M., Bistoni, Giovanni, Bohle, Fabian, Dahmani, Rahma, Firaha, Dzmitry, Gottschalk, Hannes C., Grimme, Stefan, Hansen, Andreas, Harding, Michael E., Hochlaf, Majdi, Holzer, Christof, Jansen, Georg, Klopper, Wim, Kopp, Wassja A., Kröger, Leif C., Leonhard, Kai, Mata, Ricardo A., Mouhib, Halima, Neese, Frank, Pereira, Max N., Poblotzki, Anja, Suhm, Martin A., Ulusoy, Inga S., Wuttke, Axel   +27 more
core   +4 more sources

Double Blind Study

, 2019
A clinical research study or a clinical trial is an experiment or observation performed on human subjects to generate data on the safety and efficacy of various biomedical and behavioral interventions.
S. David, Paras B. Khandhar
semanticscholar   +1 more source