Results 51 to 60 of about 1,233,954 (328)

Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study [PDF]

, 2014
Design: Phase 1, randomized, two-site (US), double-blind, placebo-controlled study of sexually-abstinent males and ...
Anton, PA, Bumpus, NN, Cranston, RD, Elliott, J, Hendrix, CW, Kashuba, A, Mauck, C, McGowan, I, Richardson-Harman, N, Tanner, K, Yang, K   +10 more
core   +4 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Moving to the Double-Blind Review System

Journal of Intelligence, 2015
The Journal of Intelligence presently has a single-blind peer review system, unlike most other journals in the social sciences, where the double-blind peer review prevails. The choice between the two systems is not easy.
Paul De Boeck
doaj   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Long-term treatment of uterine fibroids with ulipristal acetate [PDF]

, 2014
Objective: To investigate the efficacy and safety of ulipristal acetate (UPA) for long-term treatment of symptomatic uterine fibroids.<p></p> Design: Repeated intermittent open-label UPA courses, each followed by randomized double-blind ...
Bart C.J.M. Fauser, Brown, Busfield, David H. Barlow, Dolan, Donnez, Donnez, Donnez, Donnez, Elke Bestel, Ernest Loumaye, Fiscella, Fiscella, Francisco Vázquez, Gainer, Higham, Higham, Horak, Ian Osterloh, Ioffe, Jacques Donnez, Janssen, Janusz Tomaszewski, Kadir, Kazem Nouri, Kim, Kim, Kouides, Kriplani, Lethaby, Levens, Mehine, Melis, Melzack, Melzack, Mutter, Mutter, Nieman, Olivier Donnez, Philipp, Philippe Bouchard, Pohl, Reid, Santiago Palacios, Scialli, Spies, Spies, Spies, Stewart, Stewart, Takeda, Wallach, Williams, Williams, Zakherah, Zapata   +55 more
core   +1 more source

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source

Randomized, Controlled Study of Adderall XR in ADHD

Pediatric Neurology Briefs, 2002
The efficacy and safety of Adderall XR in the treatment of attention deficit/hyperactivity disorder and diurnal variation in responses were assessed by a multicenter, randomized, double-blind, parallel group, placebo-controlled trial at 47 sites, and ...
J Gordon Millichap
doaj   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source

Tolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode

Brain Stimulation, 2023
Background: Few studies have investigated tolerability, blinding, and double-blinding of High-Definition transcranial Direct Current Stimulation (HD-tDCS) at amplitudes above 2 milliamps (mA).
Carine El Jamal, Ashley Harrie, Annalise Rahman-Filipiak, Alexandru D. Iordan, Alexandre F. DaSilva, Robert Ploutz-Snyder, Lara Khadr, Michael Vesia, Marom Bikson, Benjamin M. Hampstead   +9 more
doaj  

Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease

npj Parkinson's Disease, 2022
Balance dysfunction is a disabling symptom in people with Parkinson’s disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects.
Malin Freidle, Hanna Johansson, Urban Ekman, Alexander V. Lebedev, Ellika Schalling, William H. Thompson, Per Svenningsson, Martin Lövdén, Alonso Abney, Franziska Albrecht, Hanna Steurer, Breiffni Leavy, Staffan Holmin, Maria Hagströmer, Erika Franzén   +14 more
doaj   +1 more source