Results 131 to 140 of about 12,867,784 (306)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Effect of rosuvastatin on diabetic polyneuropathy: a randomized, double-blind, placebo-controlled Phase IIa study

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2014
Jaime Hernández-Ojeda, Luis Miguel Román-Pintos, Adolfo Daniel Rodríguez-Carrízalez, Rogelio Troyo-Sanromán, Ernesto Germán Cardona-Muñoz, María del Pilar Alatorre-Carranza, Alejandra Guillermina ...
Hernández-Ojeda J   +6 more
doaj  

The double-edged nature of nicotine: toxicities and therapeutic potentials

open access: yesFrontiers in Pharmacology
Nicotine is the primary addictive component of cigarette smoke and is associated with various smoking-related diseases. However, recent research has revealed its broader cognitive-enhancing and anti-inflammatory properties, suggesting its potential ...
Yun Cao   +12 more
doaj   +1 more source

Greenhouse effect in double-skin facade

open access: yes, 2007
In these last years, a great deal of interest has been devoted to double-skin facades due to the advantages claimed by this technology (in terms of energy saving in the cold season, high-tech image, protection from external noise and wind loads).
Gratia, Elisabeth, De Herde, André
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Magnetic-field-induced nondipole effect in strong field frustrated double ionization

open access: yesNew Journal of Physics
Strong field atomic frustrated double ionization (FDI) represents a novel approach for ultrafast preparation and control of highly excited ions. A comprehensive understanding of its mechanism is of fundamental significance.
Linna Zhang   +4 more
doaj   +1 more source

The Principle of Double Effect within Catholic Moral Theology: A Response to Two Criticisms of the Principle in Relation to Palliative Sedation [PDF]

open access: yes, 2017
If not considered an isolated principle but as part of Catholic moral theology, the principle of double can serve as an aid to discernment of the morality of an action, as one moral principle in the context of a broader moral system.
Gina Maria Noia
core  

Double-vault composting latrine

open access: yes, 2019
Double-vault composting ...
Rod Shaw (1258020)   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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