Results 31 to 40 of about 1,606,571 (253)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ciência Rural, 1995 O consórcio,de substituição, em que a segunda cultura é implantada após a primeira ter atingido a antese, é um sistema que apresenta grande potencial de utilização na pequena propriedade.
Andréa Brondani da Rocha +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Laughing all the way to the bank? Alternative comedy in the provinces
, 1994 Metropolitan snobbery and the logistics of scale both militate against the success of comedians working in the regions. Yet, as Oliver Double here argues, the scene has been a lively one, often daring in its style and range alike – at least until the ...
Double, Oliver
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Anatomical Study on the Multi-Ovule Development and Abortion of Hanfu Apple
Journal of Integrative Agriculture, 2014 The terminal flower buds of 6-yr-old Hanfu apple were used to study the ovule development, ovular characteristics, cell death of abortive ovules, and dynamic change of starch grain quantity in the embryo sac with paraffin slices and terminal ...
Xu-yuan YANG +5 more
doaj +1 more source
Irrigation has more influence than fertilization on leaching water quality and the potential environmental risk in excessively fertilized vegetable soils. [PDF]
PLoS ONE, 2018 Excessive fertilization is a common agricultural practice that often negatively influence soil and environmental quality in intensive vegetable production systems in China.
Yang Li +3 more
doaj +1 more source
Three Cell Fusions during Double Fertilization [PDF]
, 2015 Fertilization of both egg and central cell is a major distinguishing feature of flowering plants. Now, Maruyama et al. report a third cell fusion event between the persistent synergid and the fertilized central cell shortly after double fertilization in ...
Dresselhaus, Thomas, Sprunck, Stefanie
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source