Results 91 to 100 of about 1,476,773 (274)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Stability Analysis of Curved Beams Based on First-Order Shear Deformation Theory and Moving Least-Squares Approximation

Buildings
Based on the first-order shear deformation theory (FSDT) and moving least-squares approximation (MLS), a new meshfree method that considers the effects of geometric nonlinearity and the pre- and post-buckling behaviors of curved beams is proposed.
Yuxiao Li, Yajing Liao, Zhen Xie, Linxin Peng   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Long range effects on the optical model of 6He around the Coulomb barrier

, 2010
We present an optical model (OM) analysis of the elastic scattering data of the reactions 6He+27Al and 6He+208Pb at incident energies around the Coulomb barrier.
A.M. Moro, Alvarez, Alvarez, Alvarez, Andrés, Andrés, Arnold, Atzrott, Austern, Barnett, Benjamim, Bonaccorso, Chamon, Chamon, Chamon, Cook, Cândido-Ribeiro, Danilin, Davinson, Di Pietro, Escrig, Fernández-Niello, Galetti, Gasques, Gomes, J.P. Fernández-García, Kailas, Kakuee, Keeley, Keeley, Keeley, Koning, Lilley, M. Rodríguez-Gallardo, M.A.G. Alvarez, Maciel, Mackintosh, Martel, Matsumoto, Matsumoto, Mohr, Nadasen, Nadasen, Nagarajan, Pakou, Pakou, Passatore, Passatore, Rodríguez-Gallardo, Rodríguez-Gallardo, Rodríguez-Gallardo, Rossi, Rusek, Rusek, Sakuragi, Satchler, Satchler, Silva, So, Sánchez-Benítez, Takashina, Thompson, Thompson, Thompson, Thompson, Vervier, Yahiro   +66 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

General variational many-body theory with complete self-consistency for trapped bosonic systems

, 2006
In this work we develop a complete variational many-body theory for a system of $N$ trapped bosons interacting via a general two-body potential. In this theory both the many-body basis functions {\em and} the respective expansion coefficients are treated
A. Szabo, Alexej I. Streltsov, L. P. Pitaevskii, L. P. Pitaevskii, L. Pitaevskii, Lorenz S. Cederbaum, Ofir E. Alon, P. Nozieres, P. Nozieres, R. G. Newton   +9 more
core   +1 more source

Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of the drug riamilovir for the prevention of COVID-19

Терапевтический архив
Aim. Evaluation of the efficacy and safety of riamilovir as a drug for the prevention of coronavirus infection (COVID-19) in adults who have constant contact with COVID-19 patients as a result of living together. Materials and methods.
Alebai U. Sabitov, Dmitry A. Lioznov, Konstantin V. Zhdanov, Elena P. Tihonova, Elena V. Esaulenko, Pavel V. Sorokin   +5 more
doaj   +1 more source

Sensitivity and Specificity of the Diagnostic Method for Detecting α-Synuclein as a Histological Marker for Parkinson's Disease in Salivary Gland Tissues: a Systematic Review and Meta-analysis [PDF]

Анналы клинической и экспериментальной неврологии
Immunohistochemistry of α-synuclein (α-syn), a marker for Parkinson's disease, in salivary gland (SG) biopsy specimens has been actively studied as a method of verification and early diagnosis.
Kristina K. Khacheva, Sergey N. Illarioshkin, Alexey V. Karabanov   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Two Relaxed Inertial Forward–Reflected–Backward Splitting Algorithms With Momentum Terms

Journal of Mathematics
In this paper, to solve the monotone inclusion problem consisting of the sum of two monotone operators in Hilbert spaces, we propose and study two modifications of Malitsky–Tam’s forward–reflection–backward splitting methods with double momentum terms ...
Binbin Zhang, Ximeng Guan, Chenhao Yin
doaj   +1 more source