Results 101 to 110 of about 1,476,773 (274)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

On the computation of zone and double zone diagrams

, 2017
Classical objects in computational geometry are defined by explicit relations. Several years ago the pioneering works of T. Asano, J. Matousek and T. Tokuyama introduced "implicit computational geometry", in which the geometric objects are defined by ...
A Granas, A Okabe, A Tarski, AG Corbalan, B Knaster, CK Yap, D Leven, D Reem, Daniel Reem, E Grädel, F Aurenhammer, F Aurenhammer, H Brezis, H Busemann, H Martini, H-D Ebbinghaus, J Chun, J Monterde, J-D Boissonnat, JB Wilker, K Mulmuley, M Berg de, M Ponce, M Sharir, R Fraser, S Prus, S Reich, SC Biasi de, Y Pinchover, ÁG Horváth, ÁG Horváth   +30 more
core   +1 more source

Low-Frequency Transient Model of Single-Phase Four-Limb Converter Transformer Considering the Nonlinear Excitation Characteristics of the Iron Core

Applied Sciences
Transformer modeling is a crucial method for analyzing transient phenomena such as inrush currents. The primary characteristic of a transformer transient model is its ability to reflect how the transformer’s structure and material properties influence ...
Xichen Pei, Lan Xiong, Zhanlong Zhang, Zijian Dong, Yu Yang, Jiatai Gao, Tao Feng   +6 more
doaj   +1 more source

Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.

PLoS ONE, 2013
ObjectiveTo perform a systematic review, and if possible a meta-analysis, to establish whether depressed patients with co-morbid chronic somatic illnesses are a high risk "double trouble" group for depressive recurrence.MethodThe databases PubMed, EMbase
Gemma D Kok, Claudi L H Bockting, Huibert Burger, Wiebke Hannig, Gerdina H M Pijnenborg, Pim Cuijpers, Steven D Hollon   +6 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Digital financial inclusion and comprehensive multilevel medical insurance system in China

Frontiers in Public Health
BackgroundThe influence of digital financial inclusion on medical insurance systems has drawn significant attention. However, its impact on China’s multilevel medical insurance system (MMIS) remains uncertain.
Zhe Liu, Xingyuan Wu, Xi Chen, Congzhi Qin, Zenghui Qiu, Zhuangzhi Fang, Lan Yao   +6 more
doaj   +1 more source

Method of Improving the Shape of Amplitude-Frequency Characteristics of Resonant Radio Frequency Amplifiers with Double Autotransformer Inclusion

Doklady BGUIR
Features of formation of amplitude-frequency characteristics of resonant amplifier stages with double autotransformer inclusion are considered. The amplitude-frequency characteristic of the resonant cascade was simulated using the Multisim circuit design program. The transfer function of the circuit is analyzed and the factors influencing the formation
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Numerical Computation of approximate Generalized Polarization Tensors

, 2011
In this paper we describe a method to compute Generalized Polarization Tensors. These tensors are the coefficients appearing in the multipolar expansion of the steady state voltage perturbation caused by an inhomogeneity of constant conductivity.
Capdeboscq, Yves, Karrman, Anton Bongio, Nédélec, Jean-Claude   +2 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source