Results 71 to 80 of about 1,130,446 (280)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Technology for eVTOL Cementing and Co-Curing Composite Wing Box Segment
Engineering ProceedingsIn this paper, the status quo of manufacturing technology of the wing structures of large and small general aircraft at home and abroad is reported. The existing problems in the manufacturing technology of double-beam, multi-rib composite wing structures
Shutao Qi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Unification of integral transforms and their applications
Partial Differential Equations in Applied MathematicsAn integral transform called BA-transform is introduced in this work, which yields a known number of transforms by changing variables. We prove that Laplace, Sumudu, Natural, Elzaki, Aboodh, Tarig, Srivastava, Kamal, Laplace–Carson, Mohand, Shehu and ...
A. Belafhal, R. El Aitouni, T. Usman
doaj +1 more source
Stabilization of a double inverted rotary pendulum through fractional order integral control scheme
International Journal of Advanced Robotic Systems, 2019 Rotary double inverted pendulum is a highly nonlinear complex system and requires a high performance controller for its control. Using gain matrix which is obtained through state feedback technique may create complexity while removing the steady-state ...
Ibrahim Mustafa Mehedi +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Mathematical Problems in the Theory of Bone Poroelasticity
Biomath, 2012 This paper concerns with the quasi-static theory of bone poroelasticity for materials with double porosity. The system of equations of this theory based on the equilibrium equations, conservation of fluid mass, the effective stress concept and Darcy’s ...
Merab Svanadze, Antonio Scalia
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Gong-kuang zidonghua, 2014 A suppression strategy of circulating current of modular multilevel converter based on proportional complex integral controller was proposed according to double fundamental frequency negative sequence property of phase-to-phase circulating current of ...
SONG Pinggang +3 more
doaj +1 more source