Results 151 to 160 of about 7,158 (255)

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang   +5 more
wiley   +1 more source

Life's Essential 8 and the Risk of Overall and Specific‐Site Cancer Types: A Large‐Scale Prospective Cohort Study

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background The Life's Essential 8 (LE8) framework, designed to prevent cardiovascular disease, is also linked to cancer risk, but the direct association between LE8 adherence and cancer incidence remains underexplored. Each LE8 component may affect cancer risk differently across organ systems, warranting further investigation into these ...
Li Deng   +6 more
wiley   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 46-62, January 2026.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik   +7 more
wiley   +1 more source

Clitocybe squamulosa Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Colitis by Regulating the PI3K/AKt/mTOR Pathway and the Intestinal Flora in Mice

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The potential mechanisms of CSFP and CE in alleviating UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation and ulceration of the colon. This research investigated the protective effects of Clitocybe squamulosa fruiting body polysaccharide (CSFP) and purified polysaccharides named CE on ...
Shuting Hou   +13 more
wiley   +1 more source

Exploiting Lactic Acid Bacteria for Regulating Autophagy to Improve Health in Foods and Supplements: A Recent Update

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Lactic acid bacteria (LAB) are frequently used as health supplements. They enhance digestion, regulate immunity, improve gut microbiota, and prevent and manage diseases. Autophagy has a crucial role in the prevention and treatment of tumors, cardiovascular diseases, and pathogenic infections.
Yang Chen   +8 more
wiley   +1 more source

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