Results 51 to 60 of about 2,073,173 (234)

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

1906 Double Pylorus: Case Report of Atypical Presentation

American Journal of Gastroenterology, 2019
Double Pylorus: Case Report of Atypical Presentation Christopher Lozano Orpiano DO HCA Healthcare, christopher.orpiano@hcahealthcare.com Gurjeet Kang DO HCA Healthcare, gurjeet.kang@hcahealthcare.com Michael Quinn DO HCA Healthcare, michael.quinn ...
Christopher L. Orpiano, G. Kang, M. Quinn, Lakshminarasimhan Venu, J. Staffetti   +4 more
semanticscholar   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Effect of Threonine on the Interaction Between Tau Protein Fragments and M2+ Ions (M = Ni, Cu, Zn)

European Journal of Inorganic Chemistry, EarlyView.
Structural and conformational transformations of the tau protein contribute to the development of neurodegenerative diseases. Studies indicate that threonine of the ‐ThrXaaHis‐ sequence of tau fragments and mutants affects the spectral data of copper(II) and nickel(II) complexes.
Gomaa E. Amer, Bettina D. Balogh, Balázs Sándor, Petra Bozsó, Alexandra Csiha, Petra A. Keczán, Katalin Várnagy   +6 more
wiley   +1 more source

Dual‐Functional Food‐Derived Bioactive Peptides: Expanding Beyond Biological Activity

Food Chemistry International, EarlyView.
This review examines recent advances in dual‐ and multifunctional food‐derived bioactive peptides, highlights emerging research integrating biological and techno‐functional properties, and offers perspectives to inform future studies in this field. ABSTRACT Food‐derived bioactive peptides (FBPs) are a diverse group of peptides with proven physiological
Cullen MacDonald, Xiaohong Sun
wiley   +1 more source

Clitocybe squamulosa Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Colitis by Regulating the PI3K/AKt/mTOR Pathway and the Intestinal Flora in Mice

Food Frontiers, EarlyView.
The potential mechanisms of CSFP and CE in alleviating UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation and ulceration of the colon. This research investigated the protective effects of Clitocybe squamulosa fruiting body polysaccharide (CSFP) and purified polysaccharides named CE on ...
Shuting Hou, Guangliang Ge, Ruiting Li, Defang Zhang, Wuxia Wang, Zehui Li, Naixin Duan, Lijing Xu, Yanfen Cheng, Ludan Hou, Cuiping Feng, Mingchang Chang, Junlong Meng, Xueran Geng   +13 more
wiley   +1 more source