Results 51 to 60 of about 31,082 (250)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Double Sequences and Iterated Limits in Regular Space
Formalized Mathematics, 2016 Abstract First, we define in Mizar [5], the Cartesian product of two filters bases and the Cartesian product of two filters. After comparing the product of two Fréchet filters on ℕ (F1) with the Fréchet filter on ℕ × ℕ (F2), we compare limF₁ and limF₂ for all double sequences in a non empty topological space.
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A New Outlook for Almost Convergent Sequence Spaces
Cumhuriyet Science Journal, 2018 Thepoint standing out in the present paper is the sequence spaces , and producedby the domain of the infinite matrix ,which is defined in the previous study of Candan [2], where the spaces , and ,respectively, are as presented by G.G.
Murat Candan
doaj +1 more source
Journal of Mathematics, 2021 In this study, we investigate the notions of the Wijsman ℐ2-statistical convergence, Wijsman ℐ2-lacunary statistical convergence, Wijsman strongly ℐ2-lacunary convergence, and Wijsman strongly ℐ2-Cesàro convergence of double sequence of sets in the ...
Ömer Kişi
doaj +1 more source
$\mathcal{I}_2$-Uniform Convergence of Double Sequences of Functions In $2$-Normed Spaces
Communications in Advanced Mathematical Sciences, 2022 In this work, we discuss various types of $\mathcal{I}_2$-uniform convergence and equi-continuous for double sequences of functions. Also, we introduce the concepts of $\mathcal{I}_2$-uniform convergence, $\mathcal{I}_2^*$-uniform convergence, $\mathcal ...
Mukaddes Arslan +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
On a New I-Convergent Double-Sequence Space [PDF]
International Journal of Analysis, 2013 The sequence space BVσ was introduced and studied by Mursaleen (1983). In this article we introduce the sequence space 2BVσI and study some of its properties and inclusion relations.
Khan, Vakeel A., Khan, Nazneen
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source