Results 101 to 110 of about 671,043 (291)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Statistical Convergence of Double Sequences on Probabilistic Normed Spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2007
The concept of statistical convergence was presented by Steinhaus in 1951. This concept was extended to the double sequences by Mursaleen and Edely in 2003.
S. Karakus, K. Demırcı
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The space Lq of double sequences [PDF]

open access: yes, 2009
The spaces BS, BS(t), CSp, CSbp, CSr and BV of double sequences have recently been studied by Altay and Başar [J. Math. Anal. Appl. 309(1)(2005), 70–90].
Sever, Yurdal, Başar, Feyzi
core  

On statistical convergence of double sequences of closed sets [PDF]

open access: yes, 2016
In this paper, we introduce the concepts of statistical inner and statistical outer limits for double sequences of closed sets and give some formulas for finding these limits.
Talo, Özer   +3 more
core   +1 more source

On summability of double sequences (I) [PDF]

open access: yesAnnales Polonici Mathematici, 1955
Alexiewicz, Andrzej, Orlicz, Wladyslaw
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Tauberian theorems for statistically convergent double sequences of fuzzy numbers

open access: yes, 2017
In this paper, we introduce slow oscillation and Hardy's two-sided Tauberian conditions for double sequences in n-dimensional fuzzy number space En.
Bayazit F., Talo Ö.
core   +1 more source

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