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A Positive Role in Differentiation for the Male doublesex Protein of Drosophila

Developmental Biology, 1993
The doublesex (dsx) locus encodes male-specific and female-specific polypeptides that are essential for the proper differentiation of sexually dimorphic somatic features of Drosophila melanogaster. Ectopic expression of the male-specific dsx polypeptide was obtained by P-element-mediated transformation of flies with a construct bearing a fusion between
V A, Jursnich, K C, Burtis
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Doublesex in the Middle

Science, 2002
What are the molecular mechanisms that determine the acquisition of male and female sexual characteristics? In a Perspective, Ken Burtis reviews a series of recent papers published elsewhere that elucidate the part played by the transcription factor, doublesex, in determining sexual dimorphism in the fruit fly.
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A conserved family of doublesex‐related genes from fishes

Journal of Experimental Zoology, 2002
AbstractThe sex‐determining gene Mab‐3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex‐related gene DMRT1 also encodes a conserved DM‐related DNA‐binding domain. We present here the amplification of a broad range of DM domain sequences from three fish species using degenerate ...
Xiao, Huang   +5 more
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Identification and characterization of doublesex in Bemisia tabaci

Insect Molecular Biology, 2018
Abstract Bemisia tabaci (Gennadius) is an important agricultural pest with a worldwide distribution. Although B. tabaci is known to have a unique haplodiploid reproductive strategy, its sex determination mechanism is largely unknown.
L. Guo   +8 more
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Doublesex is essential for masculinization but not feminization in Lygus hesperus

Insect Biochemistry and Molecular Biology
In most holometabolous insects, sex differentiation occurs via a hierarchical cascade of transcription factors, with doublesex (dsx) regulating genes that control sex-specific traits. Although less is known in hemimetabolous insects, early evidence suggests that substantial differences exist from more evolutionarily advanced insects.
J. Joe Hull   +7 more
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DOUBLESEX GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER

Journal of Neurogenetics, 2002
Despite several behavior-genetic studies that have suggested roles played by doublesex (dsx) in neural tissues, it has not been demonstrated that the products of this gene are actually present in the central nervous system (CNS). In this report, we describe the cellular, spatial, and temporal expression patterns of dsx gene products in the developing ...
Gyunghee, Lee   +2 more
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Doublesex: a conserved downstream gene controlled by diverse upstream regulators

Journal of Genetics, 2010
Sex determination, an integral precursor to sexual reproduction, is required to generate morphologically distinct sexes. The molecular components of sex-determination pathways regulating sexual differentiation have been identified and characterized in different organisms.
J N, Shukla, J, Nagaraju
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Faculty Opinions recommendation of doublesex is a mimicry supergene.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2014
Laurent Keller, Romain Libbrecht
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The role of the doublesex gene in tissue dimorphisms in Anopheles Gambian

2022
Genetic control has become a popular strategy for suppressing mosquito vectors of disease. Gene drives are synthetic genetic elements that are able to increase the inheritance of a desired allele to surpass mendelian levels. Gene drives targeting female fertility genes have been successfully used in the laboratory for population suppression of the ...
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