Results 181 to 190 of about 6,000 (194)

Doublesex: a conserved downstream gene controlled by diverse upstream regulators

Journal of Genetics, 2010
Sex determination, an integral precursor to sexual reproduction, is required to generate morphologically distinct sexes. The molecular components of sex-determination pathways regulating sexual differentiation have been identified and characterized in different organisms.
J N, Shukla, J, Nagaraju
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Conserved RNA cis-elements regulate alternative splicing of Lepidopteran doublesex

Insect Biochemistry and Molecular Biology, 2014
Doublesex (dsx) is a downstream key regulator in insect sex determination pathway. In Drosophila, alternative splicing of Dm-dsx gene is sex-specifically regulated by transformer (tra), in which the functional TRA promotes female-specific Dm-dsx.
Xiu-Ye Wang, Zeng-Zhang Zheng, Hong-Sheng Song, Yong-Zhen Xu   +3 more
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Identification and characterization of doublesex in Bemisia tabaci

Insect Molecular Biology, 2018
Abstract Bemisia tabaci (Gennadius) is an important agricultural pest with a worldwide distribution. Although B. tabaci is known to have a unique haplodiploid reproductive strategy, its sex determination mechanism is largely unknown.
L. Guo, W. Xie, Y. Liu, Z. Yang, X. Yang, J. Xia, S. Wang, Q. Wu, Y. Zhang   +8 more
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DOUBLESEX GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER

Journal of Neurogenetics, 2002
Despite several behavior-genetic studies that have suggested roles played by doublesex (dsx) in neural tissues, it has not been demonstrated that the products of this gene are actually present in the central nervous system (CNS). In this report, we describe the cellular, spatial, and temporal expression patterns of dsx gene products in the developing ...
Gyunghee, Lee, Jeffrey C, Hall, Jae H, Park   +2 more
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Linkage between Oligomerization and DNA Binding in Drosophila Doublesex Proteins

Biochemistry, 1998
The doublesex gene of Drosophila melanogaster encodes DSXM protein in males and DSXF protein in females. Dimers of each protein bind a DNA site from which DSXM represses and DSXF activates transcription. Amino acids 1-397 are identical between the proteins and include a domain (DBD) for both DNA binding and protein oligomerization.
S, Cho, P C, Wensink
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Alternative splicing patterns of doublesex reveal a missing link between Nix and doublesex in the sex determination cascade of Aedes albopictus

Insect Science, 2020
AbstractSexual development in insects is regulated by a complicated hierarchical cascade of sex determination. The primary signals are diverse, whereas the central nexus doublesex (dsx) gene is relatively conserved within the pathway. Aedes (Stegomyia) albopictus is an important vector with an extensive worldwide distribution.
Binbin Jin, Yijie Zhao, Yunqiao Dong, Peiwen Liu, Yan Sun, Xiaocong Li, Xin Zhang, Xiao‐Guang Chen, Jinbao Gu   +8 more
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A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

Cell, 1993
Female-specific splicing of Drosophila doublesex (dsx) pre-mRNA is regulated by the products of the transformer (tra) and transformer 2 (tra2) genes. In this paper we show that Tra and Tra2 act by recruiting general splicing factors to a regulatory element located downstream of a female-specific 3' splice site. Remarkably, Tra, Tra2, and members of the
M, Tian, T, Maniatis
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A Positive Role in Differentiation for the Male doublesex Protein of Drosophila

Developmental Biology, 1993
The doublesex (dsx) locus encodes male-specific and female-specific polypeptides that are essential for the proper differentiation of sexually dimorphic somatic features of Drosophila melanogaster. Ectopic expression of the male-specific dsx polypeptide was obtained by P-element-mediated transformation of flies with a construct bearing a fusion between
V A, Jursnich, K C, Burtis
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Doublesex is essential for masculinization but not feminization in Lygus hesperus

Insect Biochemistry and Molecular Biology
In most holometabolous insects, sex differentiation occurs via a hierarchical cascade of transcription factors, with doublesex (dsx) regulating genes that control sex-specific traits. Although less is known in hemimetabolous insects, early evidence suggests that substantial differences exist from more evolutionarily advanced insects.
J. Joe Hull, Chan C. Heu, Roni J. Gross, Dannialle M. LeRoy, Inana X. Schutze, Daniel Langhorst, Jeffrey A. Fabrick, Colin S. Brent   +7 more
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Analysis of the biological functions of a doublesex homologue in Bombyx mori

Development Genes and Evolution, 2003
We have previously reported that Bmdsx, a homologue of the sex-determining gene doublesex ( dsx), was sex-specifically expressed in various tissues of the silkworm. The primary transcript of Bmdsx is alternatively spliced in males and females to yield sex-specific mRNAs that encode male-specific (BmDSXM) and female-specific (BmDSXF) polypeptides.
Masataka G, Suzuki, Shunsuke, Funaguma, Toshio, Kanda, Toshiki, Tamura, Toru, Shimada   +4 more
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