Results 121 to 130 of about 499,932 (244)

Semi-parametric empirical bayes method for multiplet detection in snATAC-seq with probabilistic multi-omic integration. [PDF]

PLoS Comput Biol
Wu Y, Hu H, Chen W, Gudjonsson JE, Tsoi LC, Wen X.   +5 more
europepmc   +1 more source

Experimental investigation of an interior search method within a simple framework

, 1986
A steepest gradient method for solving Linear Programming (LP) problems, followed by a procedure for purifying a non-basic solution to an improved extreme point solution have been embedded within an otherwise simplex based optimiser.
Mitra, G, Yadeger, J, Tamiz, M
core  

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Abrogation of Oncogenic RAS Signaling by a RAS(ON) Inhibitor Doublet Primes Immune-Refractory KRASG12C-Mutant NSCLC for Immune Checkpoint Blockade. [PDF]

Cancer Discov
Wei X, Blaj C, Ali Al-Radhawi M, Lai LP, Maldonato BJ, Yang YC, Seu L, Gundlapalli H, Jiang L, Moreno Ayala MA, Spradlin JN, Garrick B, Cai S, Salmon A, Pham A, Bredeson S, Liang R, Helland C, Evans JW, Labrecque MP, Yu X, Song AHJ, Dinglasan N, Tran L, Kumamoto A, Grigoryan L, Malliri A, Brown KD, Carter M, Simpson KL, Crosbie PA, Galvin M, Chang S, Huang Y, Tovbis Shifrin N, Pechuan-Jorge X, Raghulan R, Zhuang Y, Coles DI, Dive C, Aronchik I, Holderfield M, Lindsay CR, Wang Z, Wang Z, Singh M, Smith JAM, Jiang J, Quintana E.   +48 more
europepmc   +1 more source

A note on withdrawal through a point sink in fluid of finite depth

, 1996
Withdrawal flow through a point sink on the bottom of a fluid of finite depth is considered. The fluid is at rest at infinity, and a stagnation point is present at the free surface, directly above the point sink. Numerical solutions are computed by means
Hocking, Graeme C., Chandler, Graeme A., Forbes, L.K., Forbes, Lawrence K., Hocking, G.C., Chandler, G.A.   +5 more
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Untangling brain and behavioural measures of visual statistical learning: A longitudinal study in infancy. [PDF]

Dev Cogn Neurosci
Capparini C, Fourdin L, Wens V, Bertels J.   +3 more
europepmc   +1 more source

A robust feature-based registration method of multimodal image using phase congruency and coherent point drift

, 2013
This paper presents a new feature matching algorithm for nonrigid multimodal image registration. The proposed algorithm first constructs phase congruency representations (PCR) of images to be registered.
Xia RB(夏仁波), Liu YP(刘云鹏), Zhao JB(赵吉斌)   +2 more
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Early characterization of PSA dynamics in patients with metastatic hormone-sensitive prostate cancer receiving apalutamide-based regimens. [PDF]

Front Oncol
Yu P, Gao M, Li R, Hu T, Liu Z.
europepmc   +1 more source