Results 201 to 210 of about 146,014 (239)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Formal Synthesis of Ortho-Cyanated N-Heterocycles via Direct, Metal-Free Cyanation of N-Oxides Under Benign Conditions. [PDF]

Molecules
Xiao H, Wufuer R, Wang D.
europepmc   +1 more source

Dynamic Interfacial Modulation in Pt@Ga Liquid Metal Systems

Advanced Science, EarlyView.
This work introduces a facile dissolution‐reconstruction approach to prepare the Pt@Ga liquid catalyst by dissolving Pt in molten Ga and then using electrochemical treatment to reconstruct Pt on the Ga support, which provides a new design strategy for liquid‐metal catalysts and enhances the understanding of oxide‐modulated segregation, offering new ...
Zanyu Chen, Yixiao Zou, Wenda Chen, Chen Zhang, Jinfeng Zhang, Jia Ding, Xiaopeng Han, Wenbin Hu   +7 more
wiley   +1 more source

Spin-Electric Effect on a Chiral Dysprosium Complex. [PDF]

J Am Chem Soc
Tacconi L, Cini A, Raza A, Tesi L, Bartolini P, Taschin A, van Slageren J, Briganti M, Sorace L, Fittipaldi M, Perfetti M.   +10 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Can Silver(I) Act as a Hydrogen-Bond Acceptor? Spectroscopic and Computational Exploration of the Ag···H⁺ Bonds in the Gas Phase and in Solvent. [PDF]

Inorg Chem
Andris E, Straka M, Dračínský M, Yang Q, Roithová J, Rulíšek L.   +5 more
europepmc   +1 more source

Efficacy of second- and third-line chemotherapy after chemotherapy with platinum doublet and immunotherapy in non-small cell lung cancer: a descriptive study. [PDF]

Transl Cancer Res
Svaton M, Marel M, Venclicek O, Kultan J, Cernovska M, Hrnciarik M, Krejci J, Odrazka K, Domecky P.   +8 more
europepmc   +1 more source

Multistate density functional theory for local and charge-transfer tripdoublet states from triplet-free radical interactions. [PDF]

Adv Quantum Chem
Liu C, Xu Y, Bao P, Lu Y, Gao J.
europepmc   +1 more source

T cell monocyte complexes exhibit distinct immune signatures during infection. [PDF]

iScience
Kang N, Chawla A, Hillman H, Tippalagama R, Kim C, Mikulski Z, McArdle S, Seumois G, Vijayanand P, Scriba TJ, De Silva AD, Balmaseda A, Harris E, Weiskopf D, Sette A, Arlehamn CL, Peters B, Burel JG.   +17 more
europepmc   +1 more source