Results 31 to 40 of about 1,633 (266)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Primary frequency regulation strategy for doubly-fed induction generators based on virtual inertia

International Journal of Metrology and Quality Engineering
With the continuous increase of wind power generation capacity, the necessity of wind power generation participating in primary frequency regulation is also increasing.
Zhao Jingwei, Dou Zhenhai
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Research on multi-energy cooperative participation of grid frequency inertia response control strategy for energy storage type doubly-fed wind turbine considering wind speed disturbance

Frontiers in Energy Research, 2023
With the proposal of carbon peaking and carbon neutralization, the penetration rate of wind power generation continues to increase. This paper focuses on the problem that doubly fed induction wind turbines are vulnerable to input “source” disturbances ...
Dongyang Sun, Fanqi Zhao, Yifen Guo, Fanyi Meng, Wenyuan Zheng, Jixuan Yu   +5 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Simplified method of doubly fed induction generator

The Journal of Engineering, 2017
At present, doubly fed induction generator (DFIG) occupies the market of wind turbine due to its controllable rotor AC current, decoupled active and reactive power, and small converter capacity. However, the detailed model with power electronic switch components is complicated and computationally expensive for the simulation which restricts the scale ...
Guobing Song, Chenhao Zhang, Xiaobo Wang, Wei Huang   +3 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Investigation on the Modeling of Doubly-Fed Induction Generators for Wind Turbine

Algerian Journal of Signals and Systems
Over recent decades, especially in the transmission network, the share of electricity produced by wind sources has significantly increased. In order to enhance the efficiency of the power system, it is crucial to have precise and comprehensive ...
Yaakoub Diboune, Djilali Kouchih
doaj   +1 more source

Analysis of Shaft Voltage in a Doubly-fed Induction Generator

RE&PQJ
Fast switching transients and common mode voltage generated by pulse width modulated voltage in high frequency applications may cause many unwanted problems such as shaft voltage and resultant bearing currents. The main objective of this research work is to analyse shaft voltage generation in a doubly-fed induction generator (DFIG) with a back to back ...
Adabi Firouzjaee, Jafar, Zare, Firuz, Ghosh, Arindam, Lorenz, Robert   +3 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source