Results 81 to 90 of about 26,566 (274)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

open access: yesAdvanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen   +7 more
wiley   +1 more source

Control Demonstration of Multiple Doubly-Fed Induction Motors for Hybrid Electric Propulsion [PDF]

open access: yes
The Convergent Aeronautics Solutions (CAS) High Voltage-Hybrid Electric Propulsion (HVHEP) task was formulated to support the move into future hybrid-electric aircraft.
Bodson, Marc   +5 more
core   +1 more source

A new DC micro-grid system using renewable energy and electric vehicles for smart energy delivery [PDF]

open access: yes, 2010
This paper proposes a new DC micro-grid system, which fully utilizes the renewable energy and electric vehicle for smart energy delivery. The proposed DC grid incorporates the AC supply module, standby energy module, renewable energy module, and storage ...
Chau, KT   +6 more
core   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

open access: yesAdvanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao   +19 more
wiley   +1 more source

Optimisation of Magnetic Circuit for Brushless Doubly Fed Machines [PDF]

open access: yes, 2015
This paper presents an optimized design method for the magnetic circuit of brushless doubly fed machines (BDFMs). The BDFM is an attractive electrical machine, particularly for wind power applications, as a replacement for doubly fed slip-ring generators.
,   +4 more
core   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

open access: yesAdvanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong   +15 more
wiley   +1 more source

Design and analysis of a novel stator-doubly-fed doubly salient motor for electric vehicles [PDF]

open access: yes, 2005
The design of a stator-doubly-fed doubly salient (SDFDS) machine is presented. The corresponding output power equation is analytically derived. The initial calculation of motor dimensions and parameters are also discussed.
Chau, KT, Cheng, M, Fan, Y
core   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

open access: yesAdvanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl   +12 more
wiley   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

open access: yesAdvanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy