Results 71 to 80 of about 1,148,530 (239)

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome [PDF]

, 2008
Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of the human chromosome 21 (Hsa21). Recently, O’Doherty and colleagues in an earlier study generated a new genetic mouse model of DS (Tc1) that carries an almost complete ...
Morice, E., Cooke, S.F., Bliss, T.V.P., Vanes, L., Andreae, L.C., Tybulewicz, V.L.J., Fisher, E.M.C.   +6 more
core  

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Infant frontal alpha asymmetry predicts social attention and transdiagnostic risk for emotional reactivity

JCPP Advances, EarlyView.
Abstract Background Differences in Frontal Alpha Asymmetry (FAA), derived from the electroencephalogram (EEG), have been associated with approach‐withdrawal behavior, although inconsistently. The current study examined how early patterns of FAA during the first 2 years of life relate to various socioemotional characteristics (at 2 years) and ultimately
Viviane Valdes, Niccola Lutri, Haerin Chung, Charles A. Nelson   +3 more
wiley   +1 more source

Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

Clinical Medicine Insights: Reproductive Health, 2014
Objective To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice. Methods During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined ...
Merilainen Anna, Peuhkurinen Sini, Honkasalo Timppa, Laitinen Paivi, Kokkonen Hannaleena, Ryynanen Markku, Marttala Jaana   +6 more
doaj   +1 more source

Opioids and Down’s syndrome

, 2006
Opioids are used in clinical practice for sedation, anesthesia, and analgesia. Their effects depend on their pharmacokinetic and pharmacodynamic characteristics. The liver is the major site for the biotransformation of most opioids.
Vincenzo Fodale, MD, Federica Mafrica, MD   +1 more
core   +1 more source

Understanding the associations between neurodevelopmental features and internalising and externalising behaviours: A transdiagnostic approach

JCPP Advances, EarlyView.
Abstract Background Internalising and externalising behaviours—significant markers for lifetime psychiatric vulnerability—are elevated in children with neurodevelopmental diagnoses, including autism. Although neurodevelopmental features of autism are dimensions that span the population, limited research has examined their differential patterns of ...
Sarah J. Carrington, Jennifer Keating, Mirko Uljarević, Kirsten Abbot‐Smith, Catherine R. G. Jones, Susan R. Leekam   +5 more
wiley   +1 more source

Developing an integrated algorithm to support autism diagnostic decisions: Model performance and statistical fairness

JCPP Advances, EarlyView.
Abstract Background Best practices in diagnosing autism spectrum disorder require an expert diagnostician to integrate multiple sources of information, including direct observations, interviews, and rating scales completed by knowledgeable informants.
Aaron J. Kaat, Ashlynn Campagna, Hannah Feiner, Jeffrey Michael Grauzer, Amanda Nicole Hobson, Maranda Jones, Jordan Paige Lee, Laura Jean Sudec, Megan York Roberts   +8 more
wiley   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Epidemiology of Down’s syndrome in the Republic of Macedonia during the period of 1995 - 2007 [PDF]

, 2010
Down’s syndrome is an archetypal chromosome disorder and it is the first medical condition manifested as a chromosomal abnormality. The aim of this paper was to determine the incidence and prevalence rates of Down’s syndrome in the Republic of Macedonia ...
Pavlovska, Irina, Zdravkovska, Milka
core   +2 more sources