Results 131 to 140 of about 1,249,164 (307)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A child with Down syndrome [PDF]

, 2018
Ця книжка адресована батькам дітей із синдромом Дауна, корекційним педагогам і вихователям навчальних закладів. Як свідчить досвід багатьох країн світу, люди із синдромом Дауна стають повноцінними членами суспільства, діти можуть ходити у звичайні ...
Василенко-ван де Рей, А., Гладченко, І. В., Ліщук, Н.І., Чеботарьова, О. В.   +3 more
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Working memory in children with down syndrome [PDF]

, 2014
Down syndrome, characterized by cognitive impairment, a number of physical characteristics such as small chin, slanted eyes, poor muscle tone, and a flat nasal bridge, Mongoloid- like facial and multiple deformities.
Yeo, Kee Jiar, Yusoff, Shaznee Iryana
core  

Lichen Planus in Down Syndrome: Treatment with Systemic Retinoid - an Observation

, 2020
Mohammad A Hye, Siddhartha Shankar Dutta
openalex   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Healthcare and Behavior Changes for Adults With Down Syndrome 1-Year Into COVID-19 [PDF]

, 2023
Eric Rubenstein, Nichole Kyprianou, Prisha Sujin Kumar, Anna-Mariya Kriova, Alexis Sokoloff, Hampus Hillerstrom, James A. Hendrix   +6 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

PENGEMBANGAN PROGRAM INTERVENSI KECAKAPAN BERBICARA ANAK DOWN SYNDROME [PDF]

, 2015
Kemampuan berbicara dan berbahasa merupakan kemampuan awal yang harus dimiliki anak sebagai modal untuk dapat berinteraksi dan berkomunikasi. Intervensi diberikan bagi mereka yang mengalami hambatan dalam perkembangan termasuk perkembangan bicara bahasa ...
Kurniawati, Leli
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