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Nursing Children and Young People, 2016
Down's syndrome is one of the most common congenital anomalies, affecting 1:1000 infants in the UK. It occurs in people of all races, and males and females are equally affected. It was named after a British doctor who is credited as the first person to describe the condition.
Doreen Crawford, Annette Dearmun
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Down's syndrome is one of the most common congenital anomalies, affecting 1:1000 infants in the UK. It occurs in people of all races, and males and females are equally affected. It was named after a British doctor who is credited as the first person to describe the condition.
Doreen Crawford, Annette Dearmun
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Pediatric Clinics of North America, 1993
Down syndrome remains one of the most common causes of mental retardation. Although knowledge of pathogenesis remains incomplete, recent molecular biologic techniques have identified regions of the 21st chromosome critical for expression of the Down syndrome phenotype, and animal models have helped elucidate the origins of the neurochemical and ...
A, Hayes, M L, Batshaw
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Down syndrome remains one of the most common causes of mental retardation. Although knowledge of pathogenesis remains incomplete, recent molecular biologic techniques have identified regions of the 21st chromosome critical for expression of the Down syndrome phenotype, and animal models have helped elucidate the origins of the neurochemical and ...
A, Hayes, M L, Batshaw
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Current Opinion in Neurology, 1997
Down syndrome, trisomy of chromosome 21, is well investigated because it is a genetic disease with characteristic mental retardation and precocious dementia of Alzheimer type. Maternal serum markers of human chorionic gonadotrophin unconjugated estriol and amyloid precursor protein, nuchal skinfold on ultrasound and new genetic probes are developed to ...
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Down syndrome, trisomy of chromosome 21, is well investigated because it is a genetic disease with characteristic mental retardation and precocious dementia of Alzheimer type. Maternal serum markers of human chorionic gonadotrophin unconjugated estriol and amyloid precursor protein, nuchal skinfold on ultrasound and new genetic probes are developed to ...
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Down syndrome and breastfeeding
Acta Paediatrica, 2003Aim: The aim of the study was to investigate the frequency of breastfeeding among children with Down syndrome. Methods: The mothers of 560 children with Down syndrome attending four university hospitals in Italy were interviewed and the neonatal clinical records retrieved. Information was collected on the type of infant feeding and on why some mothers
Pisacane A +10 more
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Survey of Ophthalmology, 1990
Down syndrome is the most common chromosome abnormality of man. The isolated occurrence of any one of the most of the protean systemic and ocular features of Down syndrome is not specific to the disorder. The associated occurrence of several of these features, however, has distinguished affected individuals as having a distinct entity for nearly 125 ...
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Down syndrome is the most common chromosome abnormality of man. The isolated occurrence of any one of the most of the protean systemic and ocular features of Down syndrome is not specific to the disorder. The associated occurrence of several of these features, however, has distinguished affected individuals as having a distinct entity for nearly 125 ...
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The challenge of Down syndrome
Trends in Molecular Medicine, 2006Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features.
Antonarakis, Stylianos, Epstein, C. J.
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Correlation of the Down Syndrome Protein with Down Syndrome
Analytical Letters, 1990Abstract The sera of two hundred and fifty-nine individuals have been investigated for the presence of the Down syndrome protein (DSP) by a modified immunoelectrophoretic procedure. The results showed that 66.25 percent of the eighty couples with Down syndrome (DS) affected children were DSP positive which was well in accordance with the reported ...
Deborah H. Sun, Julius Kerkay
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2019
Down syndrome (DS; Trisomy 21) is the most common chromosomal disorder in humans. It has numerous associated neurologic phenotypes including intellectual disability, sleep apnea, seizures, behavioral problems, and dementia. With improved access to medical care, people with DS are living longer than ever before. As more individuals with DS reach old age,
Michael S, Rafii +3 more
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Down syndrome (DS; Trisomy 21) is the most common chromosomal disorder in humans. It has numerous associated neurologic phenotypes including intellectual disability, sleep apnea, seizures, behavioral problems, and dementia. With improved access to medical care, people with DS are living longer than ever before. As more individuals with DS reach old age,
Michael S, Rafii +3 more
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Up and down in Down's syndrome
Nature, 2014A comparison of identical human twins, only one of whom has Down's syndrome, reveals a genome-wide flattening of gene-expression levels in the affected individual. See Article p.345 Down's syndrome is thought to be caused by gene expression disturbances, so to understand the molecular mechanisms ...
David M. Gilbert, Benjamin D. Pope
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2001
Down syndrome (trisomy 21) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age dependent Alzheimer-type neurodegeneration. We tried to discuss the role of neurodevelopmental abnormalities in connection with aberrant expression of genes on chromosome 21 including amyloid precursor protein
Rainer Seidl, Gert Lubec, N. Cairns
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Down syndrome (trisomy 21) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age dependent Alzheimer-type neurodegeneration. We tried to discuss the role of neurodevelopmental abnormalities in connection with aberrant expression of genes on chromosome 21 including amyloid precursor protein
Rainer Seidl, Gert Lubec, N. Cairns
openaire +3 more sources