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Annals of the New York Academy of Sciences, 1985
Down syndrome is unique because of its preeminent role in shedding light on the biology of mental retardation. Since this disorder was first described in 1866 by John Langdon Down, the study of Down syndrome has contributed important biological knowledge and insight into normal and abnormal human development.
G F, Smith, S T, Warren
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Down syndrome is unique because of its preeminent role in shedding light on the biology of mental retardation. Since this disorder was first described in 1866 by John Langdon Down, the study of Down syndrome has contributed important biological knowledge and insight into normal and abnormal human development.
G F, Smith, S T, Warren
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The Indian Journal of Pediatrics, 1997
Down Syndrome (DS) is associated with an increased incidence of malignancies, especially leukaemias. We came across 8 DS children presenting with malignancies and having trisomy 21 as the sole cytogenetic abnormality. Of these 8 DS cases, 4 presented with acute lymphocytic leukaemia, 2 with acute myeloid leukaemia and one case each with Hodgkin's ...
P, Kusumakumary +4 more
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Down Syndrome (DS) is associated with an increased incidence of malignancies, especially leukaemias. We came across 8 DS children presenting with malignancies and having trisomy 21 as the sole cytogenetic abnormality. Of these 8 DS cases, 4 presented with acute lymphocytic leukaemia, 2 with acute myeloid leukaemia and one case each with Hodgkin's ...
P, Kusumakumary +4 more
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The electrocardiogram in Down syndrome
Cardiology in the Young, 2014AbstractDown syndrome is the most common chromosomal abnormality, with an incidence of one case in every 650 live births. It is strongly associated with heart disease, which constitutes the main cause of mortality during the first 2 years of life in this population.
Milagros, Caro +4 more
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British Journal of Psychiatry, 1993
Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning ...
S A, Cooper, R A, Collacott
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Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning ...
S A, Cooper, R A, Collacott
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Hypothyroidism in Down's Syndrome
British Journal of Psychiatry, 1988Fifty-five adult Down's syndrome subjects resident at Northgate Hospital were screened for the presence of thyroid dysfunction. Approximately 50% of the subjects had clinical features suggestive of hypothyroidism, sufficient to require thyroid-function tests.
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Illegitimacy and Down's Syndrome
Nature, 1969GERMAN recently suggested that the high prevalence of Down's syndrome among the children of older mothers results from relatively low frequencies of sexual intercourse among such mothers and a consequent increase in the probability of delay in fertilization of discharged ova1. To test this hypothesis, he suggested that the prevalence of Down's syndrome
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Pediatrics, 1990
A juvenile rheumatoid arthritis-like arthropathy has previously been documented in 12 patients with Down syndrome. An additional 9 patients are described and the literature is reviewed. It is unknown whether these patients have juvenile rheumatoid arthritis or a unique arthropathy in light of the genetic and immunologic abnormalities associated with ...
J C, Olson +4 more
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A juvenile rheumatoid arthritis-like arthropathy has previously been documented in 12 patients with Down syndrome. An additional 9 patients are described and the literature is reviewed. It is unknown whether these patients have juvenile rheumatoid arthritis or a unique arthropathy in light of the genetic and immunologic abnormalities associated with ...
J C, Olson +4 more
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THE DISTRIBUTION OF DOWN'S SYNDROME*
Journal of Intellectual Disability Research, 1982A recent increase in the incidence of Down's syndrome has been found, mainly affecting young mothers. It is concluded that this increase is due to the environment, and an association with the contraceptive pill is sought. The cause of non-disjunction is discussed and the probability of prevention suggested.
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The Indian Journal of Pediatrics, 1990
Among the 500 Down syndrome children karyotyped, 15 (3%) were due to translocation; 10 were 21;21 translocation and five 14;21. There were 9 cases of de novo translocations, while 6 were inherited from father or mother. Family history was characteristic in all the translocation cases, with younger parental age, fetal wastage in the family, recurrence ...
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Among the 500 Down syndrome children karyotyped, 15 (3%) were due to translocation; 10 were 21;21 translocation and five 14;21. There were 9 cases of de novo translocations, while 6 were inherited from father or mother. Family history was characteristic in all the translocation cases, with younger parental age, fetal wastage in the family, recurrence ...
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