Results 101 to 110 of about 11,116,554 (271)

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

DOWNLOAD FRONT MATTER

Jurnal Ilmiah Islam Futura, 2017
front matter
doaj   +1 more source

Download Table of Contents

CoSMO, 2023
Andrea Brondino, John Greaney
doaj   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Next release of the European Marine Omics Biodiversity Observation Network (EMO BON) shotgun metagenomic data from water and sediment samples (Release 2). [PDF]

Biodivers Data J
Santi I, Pavloudi C, Abagnale M, Azua I, Baña Z, Bastianini M, Belser C, Berg K, Bilbao J, Bird K, Broudin C, Camusat M, Cancio I, Caray-Counil L, Casotti R, Castel J, Comtet T, Cox CJ, Cunliffe M, Daguin C, Deneudt K, Díaz de Cerio O, Exter K, Fauvelot C, Fontana Y, Frada MJ, Galand PE, Gallia R, Garczarek L, González Fernández J, Guillou L, Heynderickx H, Koplovitz G, Labrune C, Lagaisse R, Laroquette A, Lescure L, Lopes E, Loulakaki M, Louro B, Magalhães C, Margiotta F, Moal H, Moussy A, Not F, Percopo I, Paredes Rosendo E, Péru E, Poulain J, Praebel K, Rigaut-Jalabert F, Romac S, Rzeznik-Orignac J, Sarno D, Souza Troncoso J, Thiébaut E, Thomas W, Tkacz A, Tramontano F, Trano AC, Wincker P, Pade N.   +61 more
europepmc   +1 more source

HPN Summer 2012 Download Full PDF [PDF]

, 2012

core   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

An empirical exploration of the diversified R ecosystem. [PDF]

PLoS One
Huang TY, Lou Z.
europepmc   +1 more source

HPN Summer 2011 Download Full PDF [PDF]

, 2011

core   +1 more source