Results 141 to 150 of about 11,015,246 (337)
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu+7 more
wiley +1 more source
Evaluation of the NHS active 10 walking app intervention through time-series analysis in 201,688 individuals. [PDF]
Yerrakalva D+3 more
europepmc +1 more source
The MALICIA dataset: identification and analysis of drive-by download operations
Antonio Nappa+2 more
semanticscholar +1 more source
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song+37 more
wiley +1 more source
Author Correction: Identification of metabolism‑related key genes as potential biomarkers for pathogenesis of immune thrombocytopenia. [PDF]
Xu X+10 more
europepmc +1 more source
Organization of the Proteostasis Network of Membraneless Organelles
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim+6 more
wiley +1 more source