Results 141 to 150 of about 11,301,930 (240)
Advanced Science, EarlyView.In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang +12 more
wiley +1 more source
Correction: Blindness and visual impairment in Central Europe. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source
Dynamic Synthesis of Multi‐Modal Representations for CITE‐seq Data Integration and Analysis
Advanced Science, EarlyView.The accurate integration of CITE‐seq modalities faces challenges due to complex RNA‐protein nonlinear interactions and computational inefficiencies. A lightweight framework that adaptively fuses RNA and ADT modalities, and refines them through fine‐grained learning is developed to address this issue.
Yinan Shi +5 more
wiley +1 more source
Looking beyond digital broadband speeds: Rural British Columbian's experiences with internet connectivity as a basic necessity. [PDF]
PLoS OneRush KL +4 more
europepmc +1 more source
Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma
Advanced Science, EarlyView.Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning +11 more
wiley +1 more source
Global sampling decline erodes science potential of natural history collections. [PDF]
Nat CommunForbes O, Young AG, Thrall PH.
europepmc +1 more source