Results 181 to 190 of about 11,116,554 (271)

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open access: yesRevista Lusófona de Estudos Culturais, 2017
Moisés de Lemos Martins   +1 more
openaire   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

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open access: yesInvestigación & Desarrollo, 2020
openaire   +1 more source

Correction: Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale. [PDF]

open access: yesDevelopment
Imaz-Rosshandler I   +12 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

open access: yesAdvanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen   +8 more
wiley   +1 more source

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open access: yesMediaTropes, 2013
Matthew Tiessen, Greg Elmer
doaj  

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