Results 181 to 190 of about 999,647 (302)

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Correction: Anti-vibration method for sensing ring of fiber optical current transformer integrating structural design and adaptive signal processing. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Protocol for spatially resolved pathology scores using optimal transport on spatial transcriptomics data. [PDF]

STAR Protoc
Rahman MN, Martin JF, Rahman MS, Hassan Samee MA.   +3 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Next release of the European Marine Omics Biodiversity Observation Network (EMO BON) shotgun metagenomic data from water and sediment samples (Release 2). [PDF]

Biodivers Data J
Santi I, Pavloudi C, Abagnale M, Azua I, Baña Z, Bastianini M, Belser C, Berg K, Bilbao J, Bird K, Broudin C, Camusat M, Cancio I, Caray-Counil L, Casotti R, Castel J, Comtet T, Cox CJ, Cunliffe M, Daguin C, Deneudt K, Díaz de Cerio O, Exter K, Fauvelot C, Fontana Y, Frada MJ, Galand PE, Gallia R, Garczarek L, González Fernández J, Guillou L, Heynderickx H, Koplovitz G, Labrune C, Lagaisse R, Laroquette A, Lescure L, Lopes E, Loulakaki M, Louro B, Magalhães C, Margiotta F, Moal H, Moussy A, Not F, Percopo I, Paredes Rosendo E, Péru E, Poulain J, Praebel K, Rigaut-Jalabert F, Romac S, Rzeznik-Orignac J, Sarno D, Souza Troncoso J, Thiébaut E, Thomas W, Tkacz A, Tramontano F, Trano AC, Wincker P, Pade N.   +61 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Impact of Health Care Policies on Patient Portal Adoption and Engagement in US Hospitals: Trends From 2012 to 2024. [PDF]

Adv Health Inf Sci Pract
Houser SH, Lyu W.
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

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CoSMO, 2018
Luigi Marfè
doaj   +1 more source