Development and validation of a robust cuproptosis related signature for primary glioma via machine learning aided by loop training and validation. [PDF]
Zheng Y +5 more
europepmc +1 more source
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
Feasibility of nationwide remote chronic neural data collection from recording-enabled deep brain stimulation systems. [PDF]
Mansourian KA +15 more
europepmc +1 more source
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu +8 more
wiley +1 more source
Prescriptions for Excellence in Health Care Fall 2012 Download Full Issue #17 [PDF]
core +1 more source
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
Spatial analysis of accessibility to healthcare-related facilities in Tokyo Metropolis using geographic information systems. [PDF]
Yamazaki T +10 more
europepmc +1 more source
GUTAID: a curated database linking gut microbial antigens to autoimmune mechanisms. [PDF]
Hashmi L +3 more
europepmc +1 more source

