Results 271 to 280 of about 10,165,257 (315)

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

open access: yesAdvanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong   +8 more
wiley   +1 more source

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

open access: yesAdvanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie   +7 more
wiley   +1 more source

Impact of Virus‐Mediated Modifications in Bacterial Communities on the Accumulation of Soil Organic Carbon

open access: yesAdvanced Science, EarlyView.
This study illustrates the impact of viruses on carbon cycling in soils with different availabilities of carbon. In conditions of low carbon availability, viruses adopt a lysogenic lifestyle, integrate into the host genomes and facilitate the degradation of carbon.
Mingfeng Liu   +8 more
wiley   +1 more source

ForestForward: visualizing and accessing integrated world forest data from the last 50 years. [PDF]

open access: yesDatabase (Oxford)
Tejada-Gutiérrez EL   +3 more
europepmc   +1 more source

Increasing sedentary time, minimum dietary energy requirements, and food security assessment

open access: yesApplied Economic Perspectives and Policy, EarlyView.
Abstract We compute corrections for sedentary behavior in physical activity levels (PALs) and incorporate them along with corrections for over estimation of basal metabolic rates (BMRs) into threshold caloric intakes, known as minimum dietary energy requirements (MDERs).
Jacob Michels   +2 more
wiley   +1 more source

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