Results 291 to 300 of about 11,015,246 (337)

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source

Correction: Breastfeeding transition in Oman: A generation shift or a product of social development? A qualitative study on three generations of Omani mothers. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Landscape analyses of gaps in reproductive, maternal, newborn, child, and adolescent health policies and guidelines to catalyse policy implementation improvement in Uganda. [PDF]

Health Res Policy Syst
Ibingira C, Byamugisha J, Rutebemberwa E, Atuyambe L, Mugahi R, Odongo E.   +5 more
europepmc   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

Editor's note: A Successful Launch and Thanks! [PDF]

J Mood Anxiety Disord
Strakowski SM, Wolf EJ, Ajilore O.
europepmc   +1 more source

NÚMERO COMPLETO PARA DOWNLOAD

Princípios, 2014
Eduardo (Ed.) Pellejero
doaj  

Correction: Including population and environmental dynamic heterogeneities in continuum models of collective behaviour with applications to locust foraging and group structure. [PDF]

PLoS Comput Biol
PLOS Computational Biology Staff.
europepmc   +1 more source

ClipKIT in the browser: fast online trimming of multiple sequence alignments for phylogenetics. [PDF]

Nucleic Acids Res
Steenwyk JL, Loucks JT, Buida TJ.
europepmc   +1 more source

An optimal peer selection for peer-to-peer video content distribution using fuzzy linear programming approach. [PDF]

PeerJ Comput Sci
Anandaraj M, S N.
europepmc   +1 more source