Results 121 to 130 of about 52,832 (290)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source

usiGrabber: automating the curation of proteomics spectra data at scale, making large datasets ready for use in machine learning systems. [PDF]

Bioinformatics
Auge G, Clausen M, Ketterer K, Schaefer J, Schmitt N, Altenburg T, Hartmaring Y, Raetz H, Schlaffner CN, Renard BY.   +9 more
europepmc   +2 more sources

Accountability to all four Dimensions of Health

پژوهش در دین و سلامت, 2016
For downloading the full-text of this article please click here.
Fereidoun Azizi
doaj  

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Music downloading. A comparative study between Sweden and Spain

, 2006
File sharing programs have changed the music industry in the last few years, as a lot of Internet users have started to download music. While the access to music has spread though the population of most countries, music sales have also dropped. The music
Guardia, Fransesco, Osó Alicart, Xavier
core  

An Investigation of Illegal Downloading of Music in Western Malaysia [PDF]

, 2012
This empirical study investigates the phenomenon of illegal downloading behaviour of Malaysian individuals. 434 usable responses were used in the analysis. This paper uses the theory of planned behaviour as the theoretical framework for the study.
Ferguson, Graham, Bashir, Shakeil, Phau, Ian   +2 more
core  

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Improving Multi-torrent Downloading in BitTorrent

, 2013
BitTorrent (BT)是一個廣泛被使用的點對點(peer-to-peer)檔案傳輸協定。近年來，BT的使用者通常會同時下載多個檔案，而不是一次只下載單一檔案；我們稱之為：多檔案下載。在多檔案下載環境中，BT的使用者可以使用不同的下載方式，來安排這些檔案的下載；例如使用多個session來進行多個檔案下載(multi-session下載方式)，或是只使用一個session來下載所有檔案(single-session下載方式)。此外，目前BT採取了平均分配的策略 ...
Lu, Po-Chieh, 呂柏頡
core