Results 151 to 160 of about 52,832 (290)

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Illegal music downloading in Singapore from a behavioural economics perspective.

, 2010
This paper explores the motivation behind illegal music downloading in Singapore from a behavioural economic perspective. The individual’s illegal downloading activities can be likened to cheating the record companies by a small amount. As suggested by
Ng, Li Min., Kow, Cecilia Yee Boon., Teo, Ya Chih.   +2 more
core  

GEfetch2R: fetching single-cell/bulk RNA-seq data from public repositories to R and benchmarking the subsequent format conversion tools. [PDF]

Gigascience
Song Y, Wang J, Gao J.
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

refloraR: An R package for efficiently retrieving and analyzing plant specimen data from the Herbário Virtual Reflora. [PDF]

Appl Plant Sci
Calderón Del Cid C, Versiane AFA, Leitman P, Filardi FR, Forzza RC, Cardoso D.   +5 more
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Multimedia Content Downloading In VANET with Density Estimation

, 2014
– The existence of Internet-connected navigation and infotainment systems is becoming a truth that will easily lead to a remarkable growth in bandwidth demand by in-vehicle users.
E. Lalitha, D. Jayach
core  

Beyond Screen Time: Stress, Loneliness, Emotional Competence and Problematic Internet Use in Adolescence. [PDF]

Healthcare (Basel)
Matković R, Vejmelka L.
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Impact of Different Onboarding Strategies on Low Adoption and Engagement With a Self-Monitoring and Management App for Chronic Musculoskeletal Pain: Prospective Study. [PDF]

JMIR Mhealth Uhealth
Koller CN, Blanchard M, Mettler J, Prétat T, Ming Azevedo P, Hügle T.   +5 more
europepmc   +1 more source