Results 91 to 100 of about 3,733,624 (286)
A Sustainable Approach for the Downstream Processing of Bacterial Polyhydroxyalkanoates: State-of-the-art and latest developments [PDF]
, 2019 Bioplastics have emerged as a platform to reduce our dependence on fossil fuels. Polyhydroxyalkanoates (PHAs) are a family of biodegradable polyesters with large potential in consumer goods and medical applications.
López-Gómez, J.P. +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Microbial Cell FactoriesBackground Plastic is widely utilized in packaging, frameworks, and as coverings material. Its overconsumption and slow degradation, pose threats to ecosystems due to its toxic effects. While polyhydroxyalkanoates (PHA) offer a sustainable alternative to
Vishal Ahuja +6 more
doaj +1 more source
Nanomaterials, 2015 Industrial production of menaquione-7 by Bacillus subtilis natto is associated with major drawbacks. To address the current challenges in menaquione-7 fermentation, studying the effect of magnetic nanoparticles on the bacterial cells can open up a new ...
Alireza Ebrahiminezhad +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Trends in Upstream and Downstream Process Development for Antibody Manufacturing
Bioengineering, 2014 A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes.
Petra Gronemeyer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Aqueous two-phase extraction for downstream processing of enzymes/proteins
, 1995 This chapter discusses aqueous two-phase extraction (ATPE) for downstream processing of enzymes or proteins. Downstream processing in many fermentation processes accounts for a large share of the total cost.
K.S.M.S. Raghavarao +7 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source