Results 21 to 30 of about 50,527 (161)
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia.
Blood Advances, 2021 Antibody-drug conjugates directed against tumor-specific targets have allowed targeted delivery of highly potent chemotherapy to malignant cells while sparing normal cells.
Eileen Y. Hu +20 more
semanticscholar +1 more source
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
American Journal of Respiratory and Critical Care Medicine, 2020 RATIONALE Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH).
Yuhu He +24 more
semanticscholar +1 more source
Polymers, 2021 Despite Acid Blue 113 (AB 113)’s extensive use and negative environmental impact, very few studies have focused on its efficient and environmentally friendly removal.
N. Marin, I. Stanculescu
semanticscholar +1 more source
Cancers, 2021 Simple Summary Age is one of many prognostic factors for overall survival in patients with skeletal osteosarcoma. This retrospective study provides an overview of survival in patients with high-grade osteosarcoma in different age groups.
R. Evenhuis +9 more
semanticscholar +1 more source
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Blood pressure often rises with aging, but exact mechanisms are still not completely understood.
Deping Kong +14 more
semanticscholar +1 more source
European Heart Journal, 2020 AIMS Physical activity reduces cardiovascular disease burden and mortality, although its relationship with cardiac arrhythmias is less certain. The aim of this study was to assess the association between self-reported physical activity and atrial ...
A. Elliott +10 more
semanticscholar +1 more source
, 2020 Introduction: Chimeric antigen receptor (CAR) T cell therapy directed against B-cell maturation antigen (BCMA) has shown promising results for the treatment of relapsed refractory multiple myeloma (RRMM).
M. Alsina +20 more
semanticscholar +1 more source
Clinical outcomes of 402 patients with COVID‐2019 from a single center in Wuhan, China
medRxiv, 2020 The outbreak of SARS‐CoV‐2 has become a pandemic with significant mortality. Published studies described clinical characteristics of the disease contain small cohorts from individual centers or larger series consisting of mixed series from multiple ...
Yingjie Wu +7 more
semanticscholar +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
British Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander +138 more
wiley +1 more source
Role of the L-PGDS-PGD2-DP1 receptor axis in sleep regulation and neurologic outcomes.
Sleep, 2019 To meet the new challenges of modern lifestyles, we often compromise a good night's sleep. In preclinical models as well as in humans, a chronic lack of sleep is reported to be among the leading causes of various physiologic, psychologic, and ...
A. Ahmad +4 more
semanticscholar +1 more source