Results 151 to 160 of about 106,319 (307)

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Polymers under Ionizing Radiations: the Specificity of Swift Heavy Ions

EPJ Web of Conferences, 2016
Ngono-Ravache Yvette, Ferry Muriel, Esnouf Stéphane, Balanzat Emmanuel   +3 more
doaj   +1 more source

But how does it smell? An investigation of olfactory bulb size among living and fossil primates and other euarchontoglirans

The Anatomical Record, Volume 309, Issue 4, Page 1037-1060, April 2026.
Analysis of cranial endocast data of 181 extant and 41 fossil species from Euarchontoglires shows that there was a reduction in olfactory bulb size in Crown Primates, but that there were also subsequent reductions in various other primate clades (Anthropoidea, Catarrhini, Platyrrhini, crown Cercopithecoidea, Hominoidea).
Madlen Maryanna Lang, Mary Teresa Silcox, Łucja Fostowicz‐Frelik, Adam Lis, Sergi López‐Torres, Gabriela San Martin‐Flores, Ornella C. Bertrand   +6 more
wiley   +1 more source

Updated evidence on epidemiology, diagnosis, and treatment for colonic diverticular bleeding

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Since 2020, multiple large‐scale studies (CODE BLUE‐J) in Japan have accelerated the accumulation of evidence on colonic diverticular bleeding (CDB). This review summarizes the latest findings regarding CDB epidemiology and endoscopic hemostasis.
Chikamasa Ichita, Takaaki Kishino, Tomonori Aoki, Tomohiko Machida, Takashi Murakami, Yoshinori Sato, Naoyoshi Nagata   +6 more
wiley   +1 more source

Regional Volume of Atrial Fibrillation Catheter Ablation Is Not Associated With Increased Per Capita Medical Costs

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
This ecological study of 47 Japanese prefectures demonstrates that regional medical costs are primarily driven by aging and chronic disease rather than atrial fibrillation catheter ablation, which was found to be a cost‐neutral intervention whose initial expenses are likely offset by the long‐term prevention of costly complications.
Takahiro Kamihara, Shinji Kaneko, Takuya Omura, Atsuya Shimizu   +3 more
wiley   +1 more source

Accessing intractable, phosphorylated intrinsically disordered proteins via a protease‐cleavable inclusion body tag

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Phosphorylated intrinsically disordered proteins (IDPs), such as Bcl2‐associated agonist of cell death (BAD) and Tau, play critical roles in apoptosis and neurodegeneration, yet their instability during recombinant expression due to degradation, aggregation, and dephosphorylation, has limited structural and mechanistic studies.
Cat Hoang Vesely, Stanislau Stanisheuski, Edward Lien, Patrick Reardon, Peter J. Chung, Ryan A. Mehl, Richard B. Cooley   +6 more
wiley   +1 more source

Atomically Sharp Domain Walls in an Antiferromagnet [PDF]

BIO Web of Conferences
Michalička Jan, Křížek Filip, Reimers Sonka, Kašpar Zdenek, Man Ondrej, Rusz Jan, Idrobo Juan Carlos, Wadley Peter, Jungwirth Tomas   +8 more
doaj   +1 more source

Narrative Review for the Use of Kampo Medicine During Pregnancy in Japan

Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Background Kampo medicine is commonly prescribed alongside Western pharmaceuticals. Its use during pregnancy has become increasingly common; however, there are concerns regarding safety due to the inclusion of multiple herbal components.
Ryutaro Arita, Taku Obara, Aoi Noda, Satoko Suzuki, Ken Haneda, Minoru Ohsawa, Hiromi Yoshida‐Komiya, Akiko Kikuchi, Shin Takayama, Tadashi Ishii   +9 more
wiley   +1 more source

How state transitions balance photosynthetic electron transport in plants – a quantitative study

New Phytologist, Volume 250, Issue 1, Page 209-229, April 2026.
Summary In plants, the process of state transition regulates the allocation of sunlight energy between Photosystem II (PSII) and PSI. However, the implications of state transitions for harmonizing electron transport rates between photosystems, and a full quantitative picture of this process, remain underexplored.
Haniyeh Koochak, Hui Ming Olivia Oung, Malgorzata Krysiak, Vaclav Svoboda, Helmut Kirchhoff   +4 more
wiley   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source