Results 231 to 240 of about 99,253,553 (299)

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Comparison of medication persistence and adherence in type 2 diabetes using a once-weekly regimen of DPP-4 inhibitor compared with once-daily and twice-daily regimens: a retrospective cohort study of Japanese health insurance claims data. [PDF]

Diabetol Int
Miwa T, Yoshida S, Nakajima A, Koto R, Nishimura R.   +4 more
europepmc   +1 more source

Severe Infection Outcomes With SGLT2 Versus DPP‐4 Inhibitors in Type 2 Diabetes: A Systematic Review and Active‐Comparator Meta‐Analysis of Real‐World Cohorts

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
A systematic review of 18 real‐world cohorts found no increased average risk of severe infection with SGLT2 inhibitors versus DPP‐4 inhibitors. Lower pneumonia and sepsis estimates were heterogeneous and of very low certainty; two unpooled hospitalisation estimates were of low certainty. None should be read as infection prevention.
Yung‐Ming Huang, Jen‐Hung Wang, Wan‐Ting Huang, Ji‐Ze Hsu, Soon‐Hian Teh   +4 more
wiley   +1 more source

Microalgae Proteins for Sustainable Food Systems: A Comprehensive Review of Advanced Extraction Technologies, Functional Performance, Bioactivity, and Industrial Translation

Food Frontiers, Volume 7, Issue 6, November 2026.
Microalgae proteins combine high nutritional value with low environmental impact. Advanced extraction technologies, integrated biorefineries, and AI‐driven optimization enhance protein recovery, functionality, and bioactivity, enabling applications in foods, nutraceuticals, feed, and sustainable circular bioeconomy systems.
Shuvojit Roy, Durjoy Das, Md. Hassan Bin Nabi, Animesh Sarkar, Mahabub Alam, Mukta Roy   +5 more
wiley   +1 more source

The Prescription Pattern, Care‐Seeking Behavior and Glycemic Status Among the Diabetic Patients in a Tertiary‐Level Hospital of Bangladesh: A Cross‐Sectional Observational Study

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims The prevalence of diabetes mellitus is on the rise globally, presenting a significant challenge to healthcare systems, particularly in developing countries like Bangladesh. However, treatment modalities, care‐seeking attitudes and clinical profiles among these patients are not well explored. This descriptive cross‐sectional
Md. Shamsur Rahman Sweet, Shimul Halder, Mst. Rikta Banu, Most. Chand Sultana Khatun, Md. Abdul Muhit   +4 more
wiley   +1 more source

Improvement of Glycemia by DPP-4 Inhibitors

Journal of the Japan Diabetes Society, 2013
Nishi, Y., Fujimoto, S.
openaire   +1 more source

Summary of Research: Efficacy and Safety of the SGLT2 Inhibitor Empagliflozin Versus Placebo and the DPP-4 Inhibitor Linagliptin Versus Placebo in Young People with Type 2 Diabetes (DINAMO): A Multicentre, Randomised, Double-Blind, Parallel Group, Phase 3 Trial. [PDF]

Diabetes Ther
Laffel LM.
europepmc   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source