Results 111 to 120 of about 3,138,084 (331)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

THE ECONOMIC DEVELOPMENT OF THE AUSTRALIAN FOOTBALL LEAGUE [PDF]

open access: yes
This paper begins with a brief review of the evolution of the unique brand of Australian football and the development of a fully-professional and national Australian Football League (AFL) comprising 16 clubs from the Victorian Football League (VFL ...
Ross Booth
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Obras complementarias e instalaciones accesorias en la zona de servidumbre de protección

open access: yesRevista Vasca de Administración Pública, 2014
The litoral, the coast and the protection easement have secularly been controversial spaces. Act 2/2013 on protection and sustainable use of litoral and of modification of Act of Coasts has came to add feelings and mixed opinions.
Juan Francisco Pérez Gálvez
doaj   +1 more source

Allowing the Bicycle's Drafting Rule in Triathlon

open access: yesJAPAN JOURNAL OF SPORT SOCIOLOGY, 1997
今日のスポーツ界は商業主義に大きく影響され, 競技スポーツは観客を楽しませる機能を持ち合わせていることが必要とされる。こうした現象はマス・メディアやスポンサー企業とスポーツとの在り方に起因すると考えられる。本研究では商業主義化がトライアスロンのレース形式, とりわけ競技ルールに与えた影響について明らかにする。トライアスロンは一般的に「過酷な耐久スポーツ」として知られていたが, 近年になって世界的主要レースのエリート部門ではバイク競技においてドラフティング・ルールが解禁され,「見るスポーツ」の要素を持つようになった。本来トライアスロンは, 他の選手の力を借りずに個人の力でスイム, バイク, ランを遂行するスポーツであったが, 同ルールの解禁はトライアスロンの本質を変える可能性がある ...
openaire   +1 more source

Long term integrity for space station power systems [PDF]

open access: yes
A study was made of the High Temperature Design Codes ASME N47, British R5, and the French RCC-MR Rules. It is concluded that all these codes provide a good basis of design for space application.
Leckie, F. A., Marriott, D. L.
core   +1 more source

The lobbying you have never heard of: targeting the US President’s Office of Information and Regulatory Affairs [PDF]

open access: yes, 2015
Lobbying has become a pervasive part of American politics with hundreds of organizations lobbying bills across thousands of issues. But, write Simon F. Haeder and Susan Webb Yackee, legislative lobbying is only half the story.
Haeder, Simon F., Webb Yackee, Susan
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

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