Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Scalable Manufacturing of Roll‐to‐Roll Slot‐Die Coated Perovskite Solar Cells
Advanced Science, EarlyView.Roll‐to‐roll (R2R) slot‐die coating is emerging as a scalable pathway for perovskite solar cells. This mini‐review summarizes advances in ink design, drying control, and electrode integration that enable high‐efficiency flexible devices and modules. Challenges in throughput, stability, and sustainable processing are outlined, guiding the translation of
Farshad Jafarzadeh +5 more
wiley +1 more source
Deformation‐Induced Formation of Stray Grains in Additive Manufacturing of Single Crystals
Advanced Science, EarlyView.Stray grain formation severely limits the additive manufacturing of single‐crystal alloys. By integrating in situ synchrotron techniques, ex situ characterization, and multi‐scale multi‐physics modeling, the authors reveal that stray grains originate from dislocations at the solid‐liquid interface, rather than thermal supercooling in conventional ...
Dongsheng Zhang +11 more
wiley +1 more source
Cars on Flooded Streets: Effect of Water Depth and Car Velocity on Drag Force
International Scholastic Journal of Science, 2018 A model car was pushed and then allowed to freely decelerate through water with depths ranging from 0.0 to 4.0 cm. Water depths that submerged only the wheels, not reaching the body of the car, were tested.
Chanon Hasuwannakit +2 more
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Pellet Printing for Soft Robotic Devices
Advanced Science, EarlyView.Fused Granulate Fabrication (FGF) is established here as a reliable method for fabricating soft, airtight robotic devices. Through coordinated optimization of hardware, material selection, and process parameters, this approach enables high‐speed printing of thermoplastic elastomers with silicone‐like softness and modulus.
Yijia Wu +6 more
wiley +1 more source
A novel "twist-and-drag" loop clip technique for closure of mucosal defects after colorectal endoscopic submucosal dissection. [PDF]
EndoscopyHorikawa T, Tomita T, Shinzaki S.
europepmc +1 more source
Light‑Driven Propulsion of Graphene Aerogels in Microgravity
Advanced Science, EarlyView.Ultralight graphene aerogels convert laser light into thrust. Parabolic‐flight experiments directly compare their motion in microgravity and at 1 g, revealing order‐of‐magnitude enhancements in distance, velocity, and transient thrust when weight and friction are removed (∼50 times enhancement).
Omnia Khattab +10 more
wiley +1 more source
Fabrication and Drag Reduction Performance of Bionic Surfaces Featuring Staggered Shield Scale Structures. [PDF]
Biomimetics (Basel)Gu X, Cao P, Bai X, Fu Y.
europepmc +1 more source
Multi‐scale Optimization on Interfacial Evaporative Cooling for Photovoltaic Performance Enhancement
Advanced Science, EarlyView.This study presents a passive siphon‐driven interfacial evaporative cooling technology for photovoltaics. A multiscale multiphysics model is developed and validated experimentally. Results show that optimizing installation parameters reduces operating temperature by up to 22.3 °C and boosts power efficiency by 8.9%, offering a practical pathway for ...
Fuxiang Li +5 more
wiley +1 more source
Optimizing avian flight dynamics with a synergetic bio-inspired and machine learning approach. [PDF]
Front Robot AIKhalid W +3 more
europepmc +1 more source