Results 161 to 170 of about 37,262 (339)

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

open access: yesAging Cell, EarlyView.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh   +5 more
wiley   +1 more source

Swamped: On Depression and Vision

open access: yesAmerican Anthropologist, EarlyView.
ABSTRACT “Swamped” cracks open my experience of depression by exploring how a specific place—a swamp—acted on me to bring social and emotional injuries, but also modes of seeing that ultimately moved me out of the depression, to the fore. In writing from this specific place, I build on moments in which something—a desire for beauty, the luminosity of ...
Petra Rethmann
wiley   +1 more source

How do parasites and predators choose their victim? A trade‐off between quality and vulnerability across antagonistic interactions

open access: yesBiological Reviews, EarlyView.
ABSTRACT From blood‐sucking lice and food‐stealing gulls to pandemic‐inducing viruses and egg‐eating snakes: parasites and predators are ubiquitous in shaping ecology and evolution. Fundamental to these interactions is the way in which parasites and predators choose their victim. Here, I argue that a trade‐off between host quality and vulnerability can
Mairenn C. Attwood
wiley   +1 more source

Ecosystem services provided by spiders

open access: yesBiological Reviews, EarlyView.
ABSTRACT Spiders, ubiquitous and abundant predators in terrestrial ecosystems, often are the subjects of an unjust negative perception. However, these remarkable creatures stand as unsung heroes within our ecosystems, contributing a multitude of ecosystem services critical to human well‐being.
Pedro Cardoso   +13 more
wiley   +1 more source

TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy

open access: yesCell Proliferation, EarlyView.
TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. ABSTRACT Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that
Tianlun Zhao   +6 more
wiley   +1 more source

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