Results 81 to 90 of about 35,330 (281)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

open access: yesAdvanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin   +11 more
wiley   +1 more source

Numerical investigation on the effect of stroke plane inclination on the aerodynamic performance of dragonfly take-off flight [PDF]

open access: yesMATEC Web of Conferences
A numerical investigation is carried out to study the role of inclined stroke plane on the aerodynamic performance of a dragonfly during a take-off flight.
Tiwari Shubham   +2 more
doaj   +1 more source

The Exemplar Approach to Science and Religion [PDF]

open access: yes, 2019
We can judge whether some activities are scientific or religious, depending on how similar they are to exemplar scientific activities or to exemplar religious activities, even if we cannot specify the necessary and sufficient conditions for science and ...
Park, Seungbae
core   +3 more sources

Advanced Experiment Design Strategies for Drug Development

open access: yesAdvanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang   +3 more
wiley   +1 more source

The Australian Space Eye: studying the history of galaxy formation with a CubeSat

open access: yes, 2016
The Australian Space Eye is a proposed astronomical telescope based on a 6U CubeSat platform. The Space Eye will exploit the low level of systematic errors achievable with a small space based telescope to enable high accuracy measurements of the optical ...
Barraclough, Simon   +17 more
core   +1 more source

The M101 group complex: new dwarf galaxy candidates and spatial structure [PDF]

open access: yes, 2017
The fine details of the large-scale structure in the local universe provide important empirical benchmarks for testing cosmological models of structure formation. Dwarf galaxies are key object for such studies.
Binggeli, Bruno   +3 more
core   +2 more sources

FastCat: Autonomous Discovery of Multielement Layered Double Hydroxide Alloy Catalysts for Alkaline Oxygen Evolution Reaction

open access: yesAdvanced Intelligent Discovery, EarlyView.
A machine learning‐guided self‐driving laboratory screened over 500 nickel‐based layered double‐hydroxide catalysts for alkaline oxygen evolution. Out of the eight metals, the robot uncovered a quaternary Ni–Fe–Cr–Co catalysts requiring only 231 mV overpotential to reach 20 mA cm−2.
Nis Fisker‐Bødker   +3 more
wiley   +1 more source

Rings and Jets around PSR J2021+3651: the `Dragonfly Nebula'

open access: yes, 2008
We describe recent Chandra ACIS observations of the Vela-like pulsar PSR J2021+3651 and its pulsar wind nebula (PWN). This `Dragonfly Nebula' displays an axisymmetric morphology, with bright inner jets, a double-ridged inner nebula, and a ~30" polar jet.
Adam Van Etten   +5 more
core   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

open access: yesAdvanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen   +14 more
wiley   +1 more source

Population structure and speciation in the dragonfly Sympetrum striolatum/nigrescens (Odonata: Libellulidae): An analysis using AFLP markers

open access: yesEuropean Journal of Entomology, 2009
There has been a long-standing debate as to whether Sympetrum striolatum (Charpentier, 1840) and the darker northern form, S. nigrescens (Lucas, 1912) should be recognised as separate species of dragonfly.
Katharine A. PARKES   +4 more
doaj   +1 more source

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