We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
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ACM Transactions on Knowledge Discovery From DataConcept drift is a phenomenon where the distribution of data streams changes over time. When this happens, model predictions become less accurate. Hence, models built in the past need to be re-learned for the current data. Two design questions need to be addressed in designing a strategy to re-learn models: which type of concept drift has occurred, and
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