Results 211 to 220 of about 231,929 (266)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases. [PDF]

open access: yesBrain
Morris LA   +10 more
europepmc   +1 more source

Robust Metabolomics Data Normalization across Scales and Experimental Designs. [PDF]

open access: yesAnal Chem
Vynck M   +5 more
europepmc   +1 more source

Concept Drift Adaptation by Exploiting Drift Type

ACM Transactions on Knowledge Discovery From Data
Concept drift is a phenomenon where the distribution of data streams changes over time. When this happens, model predictions become less accurate. Hence, models built in the past need to be re-learned for the current data. Two design questions need to be addressed in designing a strategy to re-learn models: which type of concept drift has occurred, and
Shaorong Xie, Hang Yu, Xiangfeng Luo
exaly   +2 more sources

Home - About - Disclaimer - Privacy