Results 291 to 300 of about 738,625 (360)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making. [PDF]

Hum Brain Mapp
Robins PL, Gilbert JR, Luber B, Mustafa N, Bharti E, Stout JD, Carver FW, Deng ZD.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural response of RC beam-column joints reinforced with smart alloys and polyvinyl alcohol fibers. [PDF]

Sci Rep
Alqarni AS, Alshannag MJ, Higazey MM.
europepmc   +1 more source

Correction: Making scientific publishing more balanced and reversing the current dangerous drift to better support global environmental conservation and planetary health. [PDF]

Res Integr Peer Rev
Guidetti P, Bianchi CN, Baxter J, Pelke N, Boudouresque CF.   +4 more
europepmc   +1 more source

Design and Development of Sectional-Chain Silicon Drift Detectors with Diversity Elliptical-Shaped Voltage Dividers. [PDF]

Micromachines (Basel)
Ni C, Long T, Zhao J, Song X, Li X, Liu M, Liu Z, Zhu X, Li Z.   +8 more
europepmc   +1 more source

Impact of COVID-19-related data drift on machine-learning prognostic models predicting 30-day opioid-related emergency department visits, hospitalisation or mortality: a population-level administrative data study in Alberta, Canada. [PDF]

BMJ Open
Sharma V, Li W, Joon T, Dubois C, Lau D, Jess E, Lindeman C, Kain NA, Ye M, Semenchuk M, Eurich DT, Samanani S.   +11 more
europepmc   +1 more source

Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases. [PDF]

Brain
Morris LA, Suzuki H, Lee S, Jin Z, Chen BB, Marin A, Huey ED, Gazes Y, Heilbronner SR, Le Heron CJ, Vanegas-Arroyave N.   +10 more
europepmc   +1 more source

Robust Metabolomics Data Normalization across Scales and Experimental Designs. [PDF]

Anal Chem
Vynck M, Vangeenderhuysen P, De Paepe E, Nawrot T, Plekhova V, Vanhaecke L.   +5 more
europepmc   +1 more source