Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Adversarial Drift Detection in Intrusion Detection System
Dianxin kexue, 2015 The recent intrusion detection systems based on machine learning generally assume that the intrusion traffic always satisfies stationary of statistics.However,this assumption is not always held when adversaries arbitrarily alter the distribution of ...
Yaguan Qian, Xiaohui Guan
doaj +2 more sources
Exponentially Weighted Moving Average for Concept Drift Detection With Cautious Learning
IEEE AccessConcept drift detection is essential for maintaining the reliability of machine learning systems deployed in dynamic, real-world environments. Drift detectors have become increasingly important for monitoring streaming classification tasks, where models ...
Irving D. Estrada-Lopez +1 more
doaj +1 more source
Concept Drift Detection with Clustering via Statistical Change Detection Methods
, 2015 We propose a concept drift detection method utilizing statistical change detection in which a drift detection method and the Page-Hinkley test are employed.
Daniela Nicklas +11 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
PGraphD*: Methods for Drift Detection and Localisation Using Deep Learning Modelling of Business Processes. [PDF]
Entropy (Basel), 2022 Hanga KM, Kovalchuk Y, Gaber MM.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Adversarial concept drift detection under poisoning attacks for robust data stream mining. [PDF]
Mach Learn, 2022 Korycki Ł, Krawczyk B.
europepmc +1 more source