Results 141 to 150 of about 3,096,343 (252)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Towards non-parametric drift detection via Dynamic Adapting Window Independence Drift Detection (DAWIDD)

, 2020
Hinder F, Artelt A, Hammer B. Towards non-parametric drift detection via Dynamic Adapting Window Independence Drift Detection (DAWIDD).
Hammer, Barbara ; https://orcid.org/, Artelt, André ; https://orcid.org/, Hinder, Fabian   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hybrid Intrusion Detection System with Real-Time Concept Drift Detection for Enhanced IoT Security. [PDF]

Sensors (Basel)
Obaidat MA, Abouali M, Shakeel A.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

DUCAL: A malware concept drift detection and adaptation method based on active learning

Tongxin xuebao
To address the performance degradation of malware detection models based on deep learning caused by concept drift, a malicious code concept drift detection and adaptation method based on active learning is proposed.
Liu Qiang, Song Yafei, Wang Jian, Chai Jinjin   +3 more
doaj  

Advanced behavioral malware detection: a comprehensive MLOps framework with federated learning and real-time drift detection. [PDF]

Front Artif Intell
El-Hajj M, Zeineddine MAJ.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Few-shot android malware classification with quantum-enhanced prototypical learning and drift detection. [PDF]

Sci Rep
Tawfik M, Tawfik M, Tarazi H, Dalalah A, Bajeszeyadaljunaeidia, Shaban WM, Fathi IS.   +6 more
europepmc   +1 more source