Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Performance Evaluation of Structural Health Monitoring Anomaly Data Processing Algorithms in Resource-Constrained Edge Computing. [PDF]
Sensors (Basel)Lei K, Li Y, Hou S, Yan W, Qin Y, Zuo F.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Repetitive negative thinking is associated with conflict-related neural activity that modulates evidence accumulation. [PDF]
J Mood Anxiety DisordWilliams L +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation. [PDF]
Biosensors (Basel)Roy N, Powers M, Gonzalez M, Cucullo L.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Opening the black box toward a modular approach to spike sorting. [PDF]
ElifeGarcia S +8 more
europepmc +1 more source
Rapid Radio Map Construction via Vehicle-Based SLAM in GNSS-Denied Environments. [PDF]
Sensors (Basel)Shin B, Kim T, Lee T.
europepmc +1 more source
Halide-Gradient Sidewall Heterojunctions for Lateral Charge Confinement in Perovskite Single Crystal x-ray Detectors. [PDF]
Small MethodsByun J +9 more
europepmc +1 more source