Results 111 to 120 of about 22,977 (217)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Experimental investigation and analysis of frictional resistance between drill pipe and cuttings bed in horizontal wells

Journal of Engineering and Applied Science
Extended-reach horizontal wells are critical for unconventional hydrocarbon development, yet cuttings accumulation frequently induces excessive drag, pipe sticking, and drilling instability.
Xiaofeng Sun, Xiaochen Jing, Shujie Liu, Yingcao Zhou, Yudong Tian, Di Yao, Jingyu Qu, Qiaobo Hu, Liang Tao, Ming Xu   +9 more
doaj   +1 more source

Failure mechanism analysis of the threaded connections of the stabilizer in bottom hole assemblies equipped with a positive displacement motor and a rotary steerable system

Advances in Mechanical Engineering
Drilling practices in Tarim Oilfield of China have shown that the combined use of a Positive Displacement Motor (PDM) and a Power Drive System can significantly enhance wellbore trajectory control and drilling efficiency, but it is likely to cause drill ...
Qinfeng Di, Heyuan Yang, Dakun Luo, Liang Wen, Tiansheng Deng, Wenchang Wang, He Zhang   +6 more
doaj   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, Volume 38, Issue 44, 7 August 2026.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

A Calculation Model for Hydraulic Cutting Torque in Offshore Oil Fields Considering the Dynamics of Drill String

Shiyou jixie
Hydromechanical cutters are commonly used in offshore oilfields to cut previous sand-control strings and casing during wellbore preparation prior to the drilling of adjustment wells.
Hu Jinyang, Xu Gang, Jia Lixin, Zhang Shuai, Zhou Jianhui, Zhang Hui   +5 more
doaj  

Research and Application of Optimal Placement of Hydraulic Oscillator

Shiyou jixie, 2016
Sliding drilling in complex well often encounters serious weight stacking,resulting in inadequate WOB and low ROP.Hydraulic oscillator introduces an axial oscillating motion on the drilling string by axial vibration,so to transfer the static friction ...
Zhang Kang, Feng Qiang, Wang Jianlong, Zhang Ruguang, Yu Zhiqiang, Xia Heming   +5 more
doaj  

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, Volume 13, Issue 43, 3 August 2026.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Analysis of drilling vibration characteristics of anchoring system in coal mine. [PDF]

Sci Rep, 2023
Xie M, Li Y, Zhang H, Yang Z, Ren Z, Nie R.   +5 more
europepmc   +1 more source

Supramolecularly Crosslinked Self‐Healable Polymer Hydrogels for Adaptive Energy Dissipation and Fragile‐System Protection

Aggregate, Volume 7, Issue 8, August 2026.
A biodegradable double‐network hydrogel combines boronate ester covalent bonds and supramolecular G4‐quartet structures to absorb impact energy and quickly self‐heal. The robust AGK hydrogel shows low rebound, high load‐bearing capacity (∼5.4 kg), and repeated durability, making it promising for protecting fragile items and sustainable shock‐absorbing ...
Dineshkumar Bharathidasan, Chandan Maity
wiley   +1 more source

Integrative in silico and in vitro screening of small molecules targeting RNA

Current Protocols, Volume 6, Issue 8, August 2026.
Abstract Targeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentally validated workflow for the integrative in silico and in vitro screening of RNA‐binding small molecules.
Sabrina Toews, Megan Ken, Harald Schwalbe   +2 more
wiley   +1 more source